Definiens Tissue Studio 2.0 Supports Tumor#Profiling, Multiplexing and Biomarker#Translational Research

Munich, Germany / Parsippany, New Jersey – August 3, 2010 – Definiens today announced the introduction of Definiens Tissue Studio™ 2.0, the latest version of the company’s leading image analysis software for digital pathology.

Since its introduction in 2009, Definiens Tissue Studio has become established as the industry’s most comprehensive image analysis software for biomarker translational research. In a wide array of different tissue stains, the out-of-the-box software automatically and accurately detects and measures cells and sub-cellular components within regions of interest. It provides cell-by-cell quantification of protein expression and describes cellular morphology.

Along with improved processing speed, the second iteration of Definiens Tissue Studio now includes a full range of functionality for the analysis of immunofluorescence tissue stains. Up to twelve immunofluorescence channels per image are supported. It also includes more accurate nucleus detection. Definiens Tissue Studio 2.0 maintains the system’s easy-to-use interface and streamlined workflow. With its “learn-by-example” format, users train the software to identify representative regions of interest, and configure the software to automatically identify cells and sub-cellular objects. Beside the analysis of whole virtual slides, Definiens Tissue Studio 2.0 also provides full support to process tissue micro arrays. Pathologists do not need prior computer programming, and can develop customized image analysis solutions in as little as 20 minutes.

“The fantastic reception to Definiens Tissue Studio over the last year has demonstrated the growing need among pathologists for accurate biomarker detection and quantification tools. The quality and significance of data generated from tissue slide analyses depend on the accuracy and consistency of the detection tools utilized,” said Martin Baatz, Ph.D. Vice President of Marketing at Definiens. “With Definiens Tissue Studio 2.0, we are providing an increased level of accuracy and speed while preserving the accessible interface and workflow that has been embraced by our customers.”

Definiens Tissue Studio 2.0 allows users to train the software on multiple images simultaneously and supports batch processing of slides or tissue microarray cores. This enables rapid identification and quantification of biomarkers across various cells and sub-cellular compartments. The software is able to quantify localized biomarker expression as well as more than 50 morphological features. The rapid and accurate results provided by the software reveal underlying biological insights required for successful oncology translational research; supporting retrospective studies, diagnostics development, and early decision support in Phase I and Phase II clinical trials.
Beta testers of the latest version of Definiens Tissue Studio 2.0 at the University of Edinburgh utilized the software in the cell-by-cell analyses of immunohistochemistry (IHC) and immunofluorescence assays derived from cell cultures and tissue specimens. The software successfully measured morphological changes to provide researchers with a detailed understanding of the dynamics of cellular change.

"Understanding cell morphologies is central to our work at the Breakthrough Research Unit,” said Elad Katz, Ph.D. at the Western General Hospital at the University of Edinburgh. “We are extremely impressed with the ability of Definiens Tissue Studio 2.0 to reliably and accurately analyze our immunofluorescence studies, providing detailed morphological information about cell size, length and interrelations to neighboring cellular structures. We have not encountered any other software able to provide such an accurate and detailed perspective."

Definiens will officially introduce Definiens Tissue Studio 2.0 during an interactive webinar on Wednesday, August 4 at 11:00 A.M. (EDT). Additionally, the company will highlight and demonstrate the software at the Intercongress Meeting of the European Society of Pathology in Kraków, Poland (August 31 – September 3, http://www.esp-congress.org/) and Pathology Informatics 2010 in Boston, Massachusetts (September 19 - 22, http://www.pathinformatics.pitt.edu/). Details and webinar registration information are available at www.tissuestudio.com.

About Definiens

Definiens is the number one Enterprise Image Intelligence company for analyzing and interpreting images on every scale - from microscopic cell structures to full body scans. The Definiens Cognition Network Technology®, developed by Nobel laureate Prof. Gerd Binnig and his team, is an advanced and robust context-based technology designed to fulfill the image analysis requirements of the Healthcare markets. It is modeled on the powerful human cognitive perception processes to extract intelligence from images.

Definiens supports biopharmaceutical companies, clinical service organizations, and academic research institutions by automating image analysis - from drug discovery to diagnostics. The company’s image analysis software enables the interpretation of vast numbers of digital images accurately and consistently. Definiens software for digital pathology and radiology images reveals biologically relevant insights for the advancement of translational research and personalized medicine. Definiens provides organizations with faster image analysis results, allowing deeper insights enabling better business decisions. The company is headquartered in Munich, Germany, and has offices throughout the United States. Further information is available at: http://www.definiens.com

Definiens, Definiens Cognition Network Technology, Definiens Cellenger, Definiens Tissue Studio, Definiens LymphExpert, Enterprise Image Intelligence and Understanding Images are trademarks or registered trademarks of Definiens.

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