A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma |

Chen R, Nishimura M C, Bumbaca S M, Kharbanda S, Forrest W F, Kasman I M, Greve J M, Soriano R H, Gilmour L L, Sanchez Rivers C, Modrusan Z, Nacu S, Guerrero S, Edgar K A, Wallin J J, Lamszus K, Westphal M, Heim S, James CD, Van den Berg S R, Costello J F

A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma: The neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation; however, instances of CD133− cells exhibiting similar properties have also been reported. Here, we show that some PTEN-deficient GBM tumors produce a series of CD133+ and CD133− self-renewing tumor-initiating cell types and provide evidence that these cell types constitute a lineage hierarchy. Our results show that the capacities for self-renewal and tumor initiation in GBM need not be restricted to a uniform population of stemlike cells, but can be shared by a lineage of self-renewing cell types expressing a range of markers of forebrain lineage. (Published in: Cancer Cell, Volume 17, Issue 4, pp 362-375)

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