Automated image analysis for tissue-based assays

Definiens automated digital pathology software guarantees accurate and consistent results for a wide range of applications in the drug development cycle. It reliably identifies tissue sections such as tumors or other morphological structures, even at the earliest stages of the onset of disease. By using Definiens’ proprietary context-based approach, the software permits the identification and detailed morphometric quantification in all types of tissue-based data - regardless of the therapeutic focus. It detects and measures a wide variety of morphological parameters including:

• Spectral statistics
• Shape
• Position
• Texture
• Relationship to neighboring structures

Definiens TissueMap

The discovery and application of oncology biomarkers has had a significant impact throughout the drug development process - together with the growing use of imaging technologies to obtain accurate measurements of disease parameters. The intelligent deployment of these technologies improves the selection and prioritization of quality candidates and helps in the elimination of poorer candidates at an early stage in the drug development process.

Definiens has developed Definiens TissueMap to support biotechnological and pharmaceutical companies in the realization of the promise of automated image analysis: Extracting maximum information from the available tissue samples.

Definiens TissueMap automates the process of analyzing tissue-based image data. It is designed for the quantitative assessment of markers of nuclei and cell body in epithelial tumors or xenografts, enabling the detailed study of human and animal tumors in animal models. The software application supports pathologists in the detection of viable and necrotic tissue in xenografts, as well as in regions of IHC (DAB) stained cells in tissue slides.

Definiens TissueMap enables researchers to

• automate and speed up the process of xenograft analysis and the detection of viable and necrotic regions.
• effectively evaluate studies using antibodies and markers of nuclei or cell body in epithelial tumors or xenografts.
• manually detect and quantify complex regions of interest in non-xenograft tumors for further analysis.
• automatically detect nuclei (IHC / DAB / hematoxilin) and regions of IHC/DAB stained cells in tissue slides.
• efficiently classify, quantify and export statistical values from stained and unstained regions of interest as well as calculate fractions/ratios, areas, number and relationships.
• improve data consistency and reproducibility in histopathological evaluations or cell proliferation studies.

With Definiens TissueMap pathologists are now able to automate the process of complex or highly apoptotic xenograft analysis in oncology research.

For further details, please download the Definiens TissueMap datasheet.

Please download a free trial version of Definiens TissueMap.