Featured Article
Varela E, Schneider RP, Ortega S, Blasco MA:
Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells
Proc Natl Acad Sci USA, Aug 24, 2011 [PMID: 21873233, Epub ahead of print]
Use Cases of Definiens Software in Digital Pathology
Definiens software works with all types of tissue stains, and can be used to auto-
matically detect regions of interest, tissue sections, specific morphologies, rare
events, cells, and sub-cellular components. Typical readouts include morphology
and protein expression profiles within specific anatomical areas, or the quantification of gene probes.
Here is a selection of Definiens use cases:
Use Cases for the Analysis of Hematoxylin & Eosin (H&E) Stained Tissue
Use Cases for the Analysis of Immunohistochemistry (IHC) Stained Tissue
Use Cases for the Analysis of Tissue Labeled through Fluorescence In-Situ|Hybridization (FISH) and Immunofluorescence (IF)
Quantification of Protein Expression on a Cell-by-Cell Basis in the Immunofluorescence (IF) Stain
Biomarker Expression Profile on a Cell-by-Cell Basis in a Highly Multiplexed Immunofluorescence (IF) Assay
Quantifying Her2 Amplification in 3D FISH for Breast Cancer Diagnostics
Quantifying Telomere Signals in 3D FISH of Zebrafish Hearts
TMA Grid Assignment and Composer Region Detection
Use Cases for the Analysis of Tissue Labeled through Silver In-Situ|Hybridization (SISH) and Chromogenic In-Situ Hybridization (CISH)
About Definiens
Definiens is the leading provider of image analysis and data mining solutions for quantitative digital pathology in the life sciences, diagnostic biomarkers and healthcare industries. Definiens software provides detailed readouts from whole tissue slides, cell-based assays and full body scans and allows correlating this information with data derived from other sources, generating new knowledge and supporting better decisions in research, diagnostics and therapy.
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