Nuclei Structures and Morphology

Nucleus detection in H&E is a challenging problem considering the variability, heterogeneity, low contrast, clustering, and differing typologies of nuclei. Once detected, however, morphological and structural characteristics can be identified and exported to serve as an extensive data source for many different research approaches, such as correlation against molecular information or patient outcomes. There are strong indications that morphological analysis in H&E can serve as a biomarker, complementing investigations typically conducted using IHC stains.

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