Dec 27, 2010
SIRT1 contributes to telomere maintenance and augments global homologous recombination
Palacios J, Herranz D, De Bonis M, Velasco S, Serrano M, Blasco M , The Journal of Cell Biology , volume 191, issue 7, pp. 1299 - 1313
Yeast Sir2 deacetylase is a component of the silent information regulator (SIR) complex encompassing Sir2/Sir3/Sir4. Sir2 is recruited to telomeres through Rap1, and this complex spreads into subtelomeric DNA via histone deacetylation. However, potential functions at telomeres for SIRT1, the mammalian orthologue of yeast Sir2, are less clear. We studied...
Nov 24, 2010
Sororin mediates sister chromatid cohesion by antagonizing Wapl.
T. Nishiyama, R. Ladurner, J. Schmitz, E. Kreidl, A. Schleiffer, V. Bhaskara, M. Bando, K. Shirahige, A. A. Hyman, K. Mechtler, J. M. Peters , Cell , DOI: 10.1016/j.cell.2010.10.031
Sister chromatid cohesion is essential for chromosome segregation and is mediated by cohesin bound to DNA. Cohesin-DNA interactions can be reversed by the cohesion-associated protein Wapl, whereas a stably DNA-bound form of cohesin is thought to mediate cohesion. In vertebrates, Sororin is essential for cohesion and stable cohesin-DNA interactions, but...
Oct 14, 2010
Structural long-term changes at mushroom body input synapses
M. C. Kremer, F. Christiansen, F. Leiss, M. Paehler, S. Knapek, T. F. Andlauer, F. Förstner, P. Kloppenburg, S. J. Sigrist, G. Tavosanis , Current Biology , DOI: 10.1016/j.cub.2010.09.060
How does the sensory environment shape circuit organization in higher brain centers? Here we have addressed the dependence on activity of a defined circuit within the mushroom body of adult Drosophila. This is a brain region receiving olfactory information and involved in long-term associative memory formation. The main mushroom body...
Oct 1, 2010
Deciphering membrane-associated molecular processes in target tissue of autoimmune uveitis by label-free quantitative mass spectrometry
Hauck SM, Dietter J, Kramer RL, Hofmaier F, Zipplies JK, Amann B, Feuchtinger A, Deeg CA, Ueffing M , Molecular & Cellular Proteomics , 2010 9, pp. 2292-2305
Autoimmune uveitis is a blinding disease presenting with autoantibodies against eye-specific proteins as well as autoagressive T cells invading and attacking the immune-privileged target tissue retina. The molecular events enabling T cells to invade and attack the tissue have remained elusive. Changes in membrane protein expression patterns between diseased and...
Aug 19, 2010
Antibody-based proteomics: fast-tracking molecular diagnostics in oncology
D. J. Brennan, D. P. O'Connor, E. Rexhepaj, F. Ponten, W. M. Gallagher , Nature Reviews Cancer , DOI: 10.1038/nrc2902
The effective implementation of personalized cancer therapeutic regimens depends on the successful identification and translation of informative biomarkers to aid clinical decision making. Antibody-based proteomics occupies a pivotal space in the cancer biomarker discovery and validation pipeline, facilitating the high-throughput evaluation of candidate markers. Although the clinical utility of these...