Nov 24, 2011
Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells
Varela E, Schneider RP, Ortega S, Blasco MA , Proc Natl Acad Sci USA , DOI: 10.1073/pnas.1105414108
Murine embryonic stem (ES) cells have unusually long telomeres, much longer than those in embryonic tissues. Here we address whether hyper-long telomeres are a natural property of pluripotent stem cells, such as those present at the blastocyst inner cell mass (ICM), or whether it is a characteristic acquired by the...
Nov 9, 2011
Systematic Analysis of Breast Cancer Morphology Uncovers Stromal Features Associated with Survival
A. H. Beck, A. R. Sangoi, S. Leung, R. J. Marinelli, T. O. Nielsen, M. J. van de Vijver, R. B. West, M. van de Rijn, D. Koller , Science Translational Medicine , DOI: 10.1126/scitranslmed.3002564
The morphological interpretation of histologic sections forms the basis of diagnosis and prognostication for cancer. In the diagnosis of carcinomas, pathologists perform a semiquantitative analysis of a small set of morphological features to determine the cancer’s histologic grade. Physicians use histologic grade to inform their assessment of a carcinoma’s aggressiveness...
Oct 17, 2011
MALDI Imaging Identifies Prognostic Seven-Protein Signature of Novel Tissue Markers in Intestinal-Type Gastric Cancer
B. Balluff, S. Rauser, S. Meding, M. Elsner, C. Schöne, A. Feuchtinger, Ch. Schuhmacher, A. Novotny, U. Jütting, G. Maccarrone, H. Sarioglu, M. Ueffing, H. Braselmann, H. Zitzelsberger, R. M. Schmid, H. Höfler, M. P. Ebert, A. Walch , The American Journal of Pathology , DOI: 10.1016/j.ajpath.2011.08.032
Proteomics-based approaches allow us to investigate the biology of cancer beyond genomic initiatives. We used histology-based matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry to identify proteins that predict disease outcome in gastric cancer after surgical resection. A total of 181 intestinal-type primary resected gastric cancer tissues from two independent patient...
May 30, 2011
Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse
Wilson DG, Phamluong K, Li L, Sun M, Cao TC, Liu PS, Modrusan Z, Sandoval WN, Rangell L, Carano RA, Peterson AS, Solloway MJ , J Cell Biol , Volume 193, Issue 5, pp 935-51
Melanoma inhibitory activity member 3 (MIA3/TANGO1/ARNT) is an evolutionarily conserved endoplasmic reticulum resident transmembrane protein. Recent in vitro studies have shown that it is required for the loading of collagen VII, but not collagen I, into COPII-coated transport vesicles. In this paper, we show that mice lacking Mia3 are defective...
May 13, 2011
Genes Associated With Prognosis After Surgery For Malignant Pleural Mesothelioma Promote Tumor Cell Survival In Vitro
G. J. Gordon, R. Bueno and D. J. Sugarbaker , BMC Cancer , DOI: 10.1186/1471-2407-11-169
Background: Mesothelioma is an aggressive neoplasm with few effective treatments, one being cytoreductive surgery. We previously described a test, based on differential expression levels of four genes, to predict clinical outcome in prospectively consented mesothelioma patients after surgery. In this study, we determined whether any of these four genes could...