Dec 31, 2014
Coronary Microvascular Rarefaction and Myocardial Fibrosis in Heart Failure With Preserved Ejection Fraction
S. F. Mohammed, MBBS; S. Hussain, MBBS; S. A. Mirzoyev, MD; W. D. Edwards, MD; J. J. Maleszewski, MD; M. M. Redfield, MD , Circulation , DOI: 10.1161/CIRCULATIONAHA.114.009625
Background: Characterization of myocardial structural changes in heart failure with preserved ejection fraction (HFpEF) has been hindered by the limited availability of human cardiac tissue. Cardiac hypertrophy, coronary artery disease (CAD), coronary microvascular rarefaction, and myocardial fibrosis may contribute to HFpEF pathophysiology.Methods and Results: We identified HFpEF patients (n=124) and...
Dec 12, 2014
Aurora kinase A is superior to Ki67 as a prognostic indicator of survival in neuroblastoma
P. Ramani, R. Nash, C. A. Rogers , Histopathology , DOI: 10.1111/his.12520
Aims: To compare the expression and prognostic value of the cell cycle markers Aurora kinase A (AURKA) and Ki67 in neuroblastoma, because AURKA expression levels have greater prognostic significance than those of Ki67 in some cancers.Methods and Results: Eighty-eight neuroblastomas were immunostained with anti-AURKA and Ki67 antibodies. Digitally scanned slides...
Dec 8, 2014
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
B. Finan, B. Yang, N. Ottaway, D. L. Smiley, T. Ma, C. Clemmensen, J. Chabenne, L. Zhang, K. M. Habegger, K. Fischer, J. E. Campbell, D. Sandoval, R. J. Seeley, K. Bleicher, S. Uhles, W. Riboulet, J. Funk, C. Hertel, S. Belli, E. Sebokova, K. Conde-Knape, A. Konkar, D. J. Drucker, V. Gelfanov, P. T. Pfluger, T. D. Müller, D. Perez-Tilve, R. D. DiMarchi, M. H. Tschöp , nature medicine , DOI: 10.1038/nm.3761
We report the discovery of a new monomeric peptide that reduces body weight and diabetic complications in rodent models of obesity by acting as an agonist at three key metabolically-related peptide hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon receptors. This triple agonist demonstrates supraphysiological potency and...
Nov 18, 2014
On the relationship between tumor structure and complexity of the spatial distribution of cancer cell nuclei: A fractal geometrical model of prostate carcinoma
P. Waliszewski, F. Wagenlehner, S. Gattenlöhner, W. Weidner , The Prostate , DOI: 10.1002/pros.22926
Background: A risk of the prostate cancer patient is defined by both the objective and subjective criteria, that is, PSA concentration, Gleason score, and pTNM-stage. The subjectivity of tumor grading influences the risk assessment owing to a large inter- and intra-observer variability. Pathologists propose a central prostate pathology review as...
Nov 6, 2014
The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells
J. Jurkin, T. Henkel, A. Færch Nielsen, M. Minnich, J. Popow, T. Kaufmann, K. Heindl, T. Hoffmann, M. Busslinger, J. Martinez , The EMBO Journal , DOI: 10.15252/embj.201490332
The unfolded protein response (UPR) is a conserved stress‐signaling pathway activated after accumulation of unfolded proteins within the endoplasmic reticulum (ER). Active UPR signaling leads to unconventional, enzymatic splicing of XBP1 mRNA enabling expression of the transcription factor XBP1s to control ER homeostasis. While IRE1 has been identified as the...