Feb 14, 2017
Inhibition of proliferation and invasion in 2D and 3D models by 2-methoxyestradiol in human melanoma cells
R.R. Massaro, F. Faião-Flores, V.W. Rebecca, S. Sandri, D.K. Alves-Fernandes, P.C. Pennacchi, K.S.M. Smalley, S.S. Maria-Engler , Pharmacological Research , DOI: 10.1016/j.phrs.2017.02.013
Despite the recent advances in the clinical management of melanoma, there remains a need for new pharmacological approaches to treat this cancer. 2-methoxyestradiol (2ME) is a metabolite of estrogen that has shown anti-tumor effects in many cancer types. In this study we show that 2ME treatment leads to growth inhibition...
Feb 13, 2017
AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations
K. Yen, J. Travins, F. Wang, M. D. David, E. Artin, K. Straley, A. Padyana, S. Gross, B. DeLaBarre, E. Tobin, Y. Chen, R. Nagaraja, S. Choe, L. Jin, Z. Konteatis, G. Cianchetta, J. O. Saunders, F. G. Salituro, C. Quivoron, P. Opolon, O. Bawa, V. Saada, A. Paci, S. Broutin, O. A. Bernard, S. de Botton, B. S. Marteyn, M. Pilichowska, Y. Xu, C. Fang, F. Jiang, W. Wei, S. Jin, L. Silverman, W. Liu, H. Yang, L. Dang, M. Dorsch, V. Penard-Lacronique, S. A. Biller, S.-S. M. Su , Cancer Discovery , DOI: 10.1158/2159-8290.CD-16-1034
Somatic gain-of-function mutations in isocitrate dehydrogenase (IDH) 1 and 2 are found in multiple hematologic and solid tumors, leading to accumulation of the oncometabolite, (R)-2-hydroxyglutarate (2HG). 2HG competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone demethylases and methylcytosine dioxygenases of the Tet family, causing epigenetic dysregulation and a block in cellular differentiation....
Feb 11, 2017
Comparative Study of Xenobiotic-free Media for the Cultivation of Human Limbal Epithelial Stem/Progenitor Cells
Dr. S. Gonzalez, Dr. L. Chen, Dr. S. X. Deng , Tissue Engineering Part C: Methods , DOI:10.1089/ten.TEC.2016.0388
The culture of human limbal epithelial stem/progenitor cells (LSCs) in the presence of animal components poses the risk of cross-species contamination in clinical applications. We quantitatively compared different xenobiotic-free culture media for the cultivation of human LSCs. LSCs were cultured from 2x2 mm limbal tissue explants on denuded human amniotic...
Jan 20, 2017
Lab on a fabric: Mass producible and low-cost fabric filters for the high-throughput viable isolation of circulating tumor cells
J. Bua, Y.-T. Kanga, Y.-S. Leeb, J. Kimc, Y.-H. Choa, B.-I. Moond , Science Direct , DOI: 10.1016/j.bios.2017.01.039
Circulating tumor cells (CTCs) play an important role in estimating the presence and the metastatic relapse of tumor. Despite of their importance, isolation of viable CTCs is still struggling, since chemical or mechanical damages are unavoidable when separating less than 1000 of CTCs out of billions of other blood components....
Jan 20, 2017
iDermatoPath – A novel software tool for mitosis detection in H&E stained tissue sections of malignant melanoma
C. Andres, B. Andres-Belloni, R. Hein, T. Biedermann, A. Schäpe, N. Brieu, R. Schönmeyer, M. Yigitsoy, J. Ring, G. Schmidt, N. Harder , Journal of the European Academy of Dermatology and Venereology , DOI: 10.1111/jdv.14126
Background: Malignant Melanoma (MM) is characterized by a growing incidence and a high malignant potential. Beside well defined prognostic factors such as tumor thickness and ulceration, the Mitotic Rate (MR) was included in the AJCC recommendations for diagnosis and treatment of MM. In daily routine, the identification of a single...