Dec 28, 2017
Intraepithelial CD8 (+) Lymphocytes as a Predictive Diagnostic Biomarker for the Remission of Oral Lichen Planus
A. Enomoto, E. Sato, T. Yasuda, T. Isomura, T. Nagao, D. Chikazu , Science Direct , DOI: 10.1016/j.humpath.2017.12.008
Oral lichen planus (OLP) is an autoimmune inflammatory disease of the oral mucosa whose etiology remains unknown. Moreover, the possibility of OLP being a premalignant change is under debate. Various types of immune cells infiltrate the OLP lesion and affect its clinicopathological features. However, the diversity of infiltrating immune cells...
Dec 26, 2017
CD44 drives aggressiveness and chemoresistance of a metastatic human osteosarcoma xenograft model
L. Mayr, C. Pirker, D. Lötsch, S. Van Schoonhoven, R. Windhager, B. Englinger, W. Berger, B. Kubista , Oncotarget , DOI: 10.18632/oncotarget.23125
Background: Osteosarcoma is the most common primary malignant bone tumor with a 5 year survival rate of up to 70%. However, patients with metastatic disease have still a very poor prognosis. Osteosarcoma metastasis models are essential to develop novel treatment strategies for advanced disease.Methods: Based on a serial transplantation approach,...
Dec 21, 2017
Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1
M. Cifdaloz, L. Osterloh, O. Graña, E. Riveiro-Falkenbach, P. Ximénez-Embún, J. Muñoz, C. Tejedo, T. G. Calvo, P. Karras, D. Olmeda, B. Miñana, G. Gómez-López, E. Cañon, E. Eyras, H. Guo, F. Kappes, P. L. Ortiz-Romero, J. L. Rodríguez-Peralto, D. Megías, J. Valcárcel, M. S. Soengas , nature communications , DOI:10.1038/s41467-017-02353-y
Melanomas are well-known for their altered mRNA expression profiles. Yet, the specific contribution of mRNA binding proteins (mRBPs) to melanoma development remains unclear. Here we identify a cluster of melanoma-enriched genes under the control of CUGBP Elav-like family member 1 (CELF1). CELF1 was discovered with a distinct prognostic value in...
Dec 21, 2017
Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML
D. Duarte, E. D. Hawkins, O. Akinduro, H. Ang, K. De Filippo, I. Y. Kong, M. Haltalli, N. Ruivo, L. Straszkowski, S. J. Vervoort, C. McLean, T. S. Weber, R. Khorshed, C. Pirillo, A. Wei, S. K. Ramasamy, A. P. Kusumbe, K. Duffy, R. H. Adams, L. E. Purton, L. M. Carlin, C. Lo Celso , Cell Stem Cell , DOI: 10.1016/j.stem.2017.11.006
Bone marrow vascular niches sustain hematopoietic stem cells (HSCs) and are drastically remodeled in leukemia to support pathological functions. Acute myeloid leukemia (AML) cells produce angiogenic factors, which likely contribute to this remodeling, but anti-angiogenic therapies do not improve AML patient outcomes. Using intravital microscopy, we found that AML progression...
Dec 16, 2017
Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin
Y. Okuda, M. Kushida, H. Kikumoto, Y. Nakamura, H. Higuchi, S. Kawamura, S. M. Cohen, B. G. Lake, T. Yamada , The Journal of Toxicological Sciences , DOI: 10.2131/jts.42.773
High dietary levels of the non-genotoxic synthetic pyrethroid momfluorothrin increased the incidence of hepatocellular tumors in male and female Wistar rats. Mechanistic studies have demonstrated that the mode of action (MOA) for momfluorothrin-induced hepatocellular tumors is constitutive androstane receptor (CAR)-mediated. In the present study, to evaluate the potential human carcinogenic...