May 18, 2017
Liver metastasis is established by metastasis of micro cell aggregates but not single cells
K. Kasuya, Y. Nagakawa, Y. Hosokawa, Y. Sahara, C. Takishita, T. Nakajima, Y. Hijikata, R. Soya, K. Katsumata, A. Tsuchida , Experimental and Therapeutic Medicine , DOI: 10.3892/etm.2017.4470
Cancer cell engraftment in the target organ is necessary to establish metastasis. Clinically, lymph node metastasis of single cells has been confirmed using cytokeratin staining. In the current study, a LacZ‑labeled cancer cell line was used to visualize intrahepatic metastasis of single cells or liver micrometastasis. KM12SM‑lacZ stably expressing LacZ...
May 17, 2017
Computer Vision Detects Subtle Histological Effects of Dutasteride on Benign Prostate Tissue
P. H. Gann, L. Sha, V. Macias, N. Kumar, Amit Sethi , The FASEB Journal , DOI: 10.1096/fj.1530-6860
Objective: Dutasteride is commonly prescribed for benign prostatic hyperplasia, to shrink the prostate by blocking formation of the potent androgen, dihydrotestosterone (DHT). Despite the drug’s dramatic effect on prostate size and growth, pathologists have struggled to identify its characteristic changes at the histological level. We studied H&E prostate biopsy images...
May 16, 2017
Unusual structures inherent in point pattern data predict colon cancer patient survival
C. M. Jones-Todd, P. Caie, J. Illian, B. C. Stevenson, A. Savage, D. J. Harrison, J. L. Bown , Annals of Applied Statistics , arXiv:1705.05938v1 [stat.ME]
Cancer patient diagnosis and prognosis is informed by assessment of morphological properties observed in patient tissue. Pathologists normally carry out this assessment, yet advances in computational image analysis provide opportunities for quantitative assessment of tissue. A key aspect of thatquantitative assessment is the development of algorithms able to link image...
May 15, 2017
Antibody–Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies
J. Rios-Doria, J. Harper, R. Rothstein, L. Wetzel, J. Chesebrough, A. Marrero, C. Chen, P. Strout, K. Mulgrew, K. McGlinchey, R. Fleming, B. Bezabeh, J. Meekin, D. Stewart, M. Kennedy, P. Martin, A. Buchanan, N. Dimasi, E. Michelotti, R. Hollingsworth , Cancer Research , DOI: 10.1158/0008-5472.CAN-16-2854
Immunogenic cell death (ICD) is the process by which certain cytotoxic drugs induce apoptosis of tumor cells in a manner that stimulates the immune system. In this study, we investigated whether antibody–drug conjugates (ADCS) conjugated with pyrrolobenzodiazepine dimer (PBD) or tubulysin payloads induce ICD, modulate the immune microenvironment, and could...
May 11, 2017
Selective targeting and therapy of metastatic and multidrug resistant tumors using a long circulating podophyllotoxin nanoparticle
A. Roy, Y. Zhao, Y. Yang, A. Szeitz,T. Klassen, S.-D. Li , Biomaterials , DOI: 10.1016/j.biomaterials.2017.05.019
Treatment options for metastatic and multidrug resistant (MDR) tumors are limited, and most of the chemotherapeutic drugs exhibit low efficacy against MDR cancers. An anti-tubulin agent podophyllotoxin (PPT) displays high potency against MDR tumor cells. However, due to its poor solubility and non-specificity, PPT cannot be used systemically. We have...