Jan 20, 2017
Lab on a fabric: Mass producible and low-cost fabric filters for the high-throughput viable isolation of circulating tumor cells
J. Bua, Y.-T. Kanga, Y.-S. Leeb, J. Kimc, Y.-H. Choa, B.-I. Moond , Biosensors and Bioelectronics , DOI: 10.1016/j.bios.2017.01.039
Circulating tumor cells (CTCs) play an important role in estimating the presence and the metastatic relapse of tumor. Despite of their importance, isolation of viable CTCs is still struggling, since chemical or mechanical damages are unavoidable when separating less than 1000 of CTCs out of billions of other blood components....
Jan 17, 2017
Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1
A. S. Nagaraj, J. Lahtela, A. Hemmes, T. Pellinen, S. Blom, J. R. Devlin, K. Salmenkivi, O. Kallioniemi, M. I. Mäyränpää, K. Närhi, E. W. Verschuren , Cell Reports , DOI: 10.1016/j.celrep.2016.12.059
Lung cancers exhibit pronounced functional heterogeneity, confounding precision medicine. We studied how the cell of origin contributes to phenotypic heterogeneity following conditional expression of KrasG12D and loss of Lkb1 (Kras;Lkb1). Using progenitor cell-type-restricted adenoviral Cre to target cells expressing surfactant protein C (SPC) or club cell antigen 10 (CC10), we...
Jan 3, 2017
Validation of Immune Cell Modules in Multicellular Transcriptomic Data
G. Pollara, M. J. Murray, J. M. Heather, R. Byng-Maddick, N. Guppy, M. Ellis, C. T. Turner, B. M. Chain, M. Noursadeghi , PloS ONE , DOI: 10.1371/journal.pone.0169271
Numerous gene signatures, or modules have been described to evaluate the immune cell composition in transcriptomes of multicellular tissue samples. However, significant diversity in module gene content for specific cell types is associated with heterogeneity in their performance. In order to rank modules that best reflect their purported association, we...
Jan 2, 2017
Strong Correlation of Indoleamine 2,3-Dioxygenase 1 Expression with Basal-Like Phenotype and Increased Lymphocytic Infiltration in Triple-Negative Breast Cancer
S. Kim, S. Park, M. S. Cho, W. Lim, B.-I. Moon, S. H. Sung , Journal of Cancer , DOI: 10.7150/jca.17437
Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunosuppressive enzyme involved in tumor immune escape. Blockade of the IDO1 pathway is an emerging modality of cancer immunotherapy. Triple-negative breast cancer (TNBC) lacks established therapeutic targets and may be a good candidate for this novel immunotherapeutic agent. The purpose of this study was...
Dec 22, 2016
Implication of the Receptor Tyrosine Kinase AXL in Head and Neck Cancer Progression
A. v. Mässenhausen, J. Brägelmann, H. Billig, B. Thewes , A. Queisser, W. Vogel, G. Kristiansen, A. Schröck, F. Bootz, P. Brossart, J. Kirfel, S. Perner , International Journal of Molecular Sciences , DOI: 10.3390/ijms18010007
Head and neck squamous cell carcinoma (HNSCC) remains a clinical challenge and identification of novel therapeutic targets is necessary. The receptor tyrosine kinase AXL has been implicated in several tumor entities and a selective AXL small molecule inhibitor (BGB324) is currently being tested in clinical trials for patients suffering from...