Sep 1, 2017
Automated detection of syncytial aggregates in digitized slide: comparison with pathologist's assessment
H. Pais, R. Shah, D. Roberts , C. Salafia , Placenta , DOI: 10.1016/j.placenta.2017.07.342
Objective: To develop an automated image analysis tool for the identification of the villous syncytium, and the quantitation of different histology features in digitized slides.Materials and Methods: Three high-resolution 2D images at 4x magnification were taken from one slide from each of the 90 placentas collected asa part of the...
Aug 25, 2017
Comprehensive Intrametastatic Immune Quantification and Major Impact of Immunoscore on Survival
B. Mlecnik, M. Van den Eynde, G. Bindea, S. E. Church, A. Vasaturo, T. Fredriksen, L. Lafontaine, N. Haicheur, F. Marliot, D. Debetancourt, G. Pairet, A. Jouret-Mourin, J.-F. Gigot, C. Hubert, E. Danse, C. Dragean J. Carrasco, Y. Humblet, V. Valge-Archer, A. Berger, F. Pagès, J.-P. Machiels, J. Galon , Journal of the National Cancer Institute , DOI: 10.1093/jnci/djx123
Background: This study assesses how the metastatic immune landscape is impacting the response to treatment and the outcome of colorectal cancer (CRC) patients.Methods: Complete curative resection of metastases (n = 441) was performed for two patient cohorts (n = 153). Immune densities were quantified in the center and invasive margin of all metastases. Immunoscore...
Aug 24, 2017
The Natural Fungal Metabolite Beauvericin Exerts Anticancer Activity In Vivo: A Pre-Clinical Pilot Study
D. Heilos, Y. Rodríguez-Carrasco, B. Englinger, G. Timelthaler, S. van Schoonhoven, M. Sulyok, S. Boecker, R. D. Süssmuth, P. Heffeter, R. Lemmens-Gruber, R. Dornetshuber-Fleiss, W. Berger , Toxins , DOI: 10.3390/toxins9090258
Recently, in vitro anti-cancer properties of beauvericin, a fungal metabolite were shown in various cancer cell lines. In this study, we assessed the specificity of this effect by comparing beauvericin cytotoxicity in malignant versus non-malignant cells. Moreover, we tested in vivo anticancer effects of beauvericin by treating BALB/c and CB-17/SCID...
Aug 22, 2017
Human Pancreatic Tumors Grown in Mice Release Tissue Factor-positive Microvesicles that Increase Venous Clot Size
Y. Hisada, C. Ay, A.C. Auriemma, B.C. Cooley, N. Mackman , Journal of Thrombosis and Haemostatis , DOI: 10.1111/jth.13809
Background: Pancreatic cancer patients have a high rate of venous thromboembolism. Human pancreatic tumors and cell lines express high levels of tissue factor (TF) and release TF-positive microvesicles (TF+MVs). In pancreatic cancer patients, tumor-derived TF+MVs are present in blood and increased levels are associated with venous thromboembolism and decreased survival....
Aug 21, 2017
Treg depletion potentiates checkpoint inhibition in claudin-low breast cancer
N. A. Taylor, S. C. Vick, M. D. Iglesia, W. J. Brickey, B. R. Midkiff, K. P. McKinnon, S. Reisdorf, C. K. Anders, L. A. Carey, J. S. Parker, C. M. Perou, B. G. Vincent, J. S. Serody , The Journal of Clinical Investigation , DOI:10.1172/JCI90499
Claudin-low breast cancer is an aggressive subtype that confers poor prognosis and is found largely within the clinical triple-negative group of breast cancer patients. Here, we have shown that intrinsic and immune cell gene signatures distinguish the claudin-low subtype clinically as well as in mouse models of other breast cancer...