Oct 11, 2017
Human adipose-derived stem cells support the growth of limbal stem/progenitor cells
H. Mei, S. González, M. N. Nakatsu, E. R. Baclagon, F. V. Chen, S. X. Deng , PLoS One , DOI: 10.1371/journal.pone.0186238
The most efficient method to expand limbal stem cells (LSCs) in vitro for clinical transplantation is to culture single LSCs directly on growth-arrested mouse fibroblast 3T3 cells. To reduce possible xenobiotic contamination from 3T3s, primary human adipose-derived stem cells (ASCs) were examined as feeder cells to support the expansion of...
Oct 7, 2017
Lack of myeloid Fatp1 increases atherosclerotic lesion size in Ldlr−/− mice
L. Zhao, A. J.Cozzo, A. R.Johnson, T. Christensen, A. J. Freemerman, J. E. Bear, J. D.Rotty, B. J. Bennett, L. Makowski , Atherosclerosis , DOI: 10.1016/j.atherosclerosis.2017.10.009
Background and aims: Altered metabolism is an important regulator of macrophage (MΦ) phenotype, which contributes to inflammatory diseases such as atherosclerosis. Broadly, pro-inflammatory, classically-activated MΦs (CAM) are glycolytic while alternatively-activated MΦs (AAM) oxidize fatty acids, although overlap exists. We previously demonstrated that MΦ fatty acid transport protein 1 (FATP1, Slc27a1)...
Oct 2, 2017
Breast cancer risk factors in relation to estrogen receptor, progesterone receptor, insulin-like growth factor-1 receptor, and Ki67 expression in normal breast tissue
H. Oh, A. H. Eliassen, A. H. Beck, B. Rosner, S. J. Schnitt, L. C. Collins, J. L. Connolly, L. Montaser-Kouhsari, W. C. Willett, R. M. Tamimi , NPJ Breast Cancer , DOI: 10.1038/s41523-017-0041-7
Studies have suggested that hormone receptor and Ki67 expression in normal breast tissue are associated with subsequent breast cancer risk. We examined the associations of breast cancer risk factors with estrogen receptor (ER), progesterone receptor (PR), insulin-like growth factor-1 receptor (IGF-1R), and Ki67 expression in normal breast tissue. This analysis...
Sep 18, 2017
103PComparison of continuous measures across diagnostic PD-L1 assays using image analysis
T. Wiestler, M. Widmaier, J. Walker, C. Barker, M. Scott, F. Sekhavati, A. Budco, K. Schneider, K. Steele, M.C. Rebelatto , Annals of Oncology , DOI: 10.1093/annonc/mdx363.019
Background: Tumour programmed cell death ligand-1 (PD-L1) expression is a key biomarker in identifying patients who may have an enhanced response to non-small cell lung cancer treatment using anti-PD-1 (e.g. nivolumab and pembrolizumab) or anti-PD-L1 (e.g. atezolizumab and durvalumab). Each treatment is currently used in conjunction with an individual PD-L1...
Sep 14, 2017
Pluripotency Surveillance by Myc-Driven Competitive Elimination of Differentiating Cells
C. Díaz-Díaz, L. Fernandez de Manuel, D. Jimenez-Carretero, M. C. Montoya, C. Clavería, M. Torres , Developmental Cell , DOI: 10.1016/j.devcel.2017.08.011
The mammalian epiblast is formed by pluripotent cells able to differentiate into all tissues of the new individual. In their progression to differentiation, epiblast cells and their in vitro counterparts, embryonic stem cells (ESCs), transit from naive pluripotency through a differentiation-primed pluripotent state. During these events, epiblast cells and ESCs are...