Sep 14, 2017
Superior reductions in hepatic steatosis and fibrosis with co-administration of a glucagon-like peptide-1 receptor agonist and obeticholic acid in mice
H. Jouihan, S. Will, S. Guionaud, M. L.Boland, S. Oldham, P.Ravn, A. Celeste, J. L.Trevaskis , Science Direct , DOI: 10.1016/j.molmet.2017.09.001
Objective: Nonalcoholic steatohepatitis (NASH) is an unmet need associated with metabolic syndrome. There are no approved therapies for NASH; however, glucagon-like peptide-1 receptor (GLP-1R) and farnesoid-X receptor (FXR) agonists are promising drug targets. We investigated the therapeutic effects of co-administration of a GLP-1R agonist, IP118, with FXR agonist obeticholic acid...
Sep 9, 2017
Multidimensional phenotyping of breast cancer cell lines to guide preclinical research
J. M. Saunus, C. E. Smart, J. R. Kutasovic, R. L. Johnston, P. Kalita-de Croft, M. Miranda, E. N. Rozali, A. C. Vargas, L. E. Reid, E. Lorsy, S. Cocciardi, T. Seidens, A. E. McCart Reed, A. J. Dalley, L. F. Wockner, J. Johnson, D. Sarkar, M. E. Askarian-Amiri, P. T. Simpson, K. K. Khanna, G. Chenevix-Trench, F. Al-Ejeh, S. R. Lakhani , Breast Cancer Research and Treatment , DOI: 10.1007/s10549-017-4496-x
Purpose: Cell lines are extremely useful tools in breast cancer research. Their key benefits include a high degree of control over experimental variables and reproducibility. However, the advantages must be balanced against the limitations of modelling such a complex disease in vitro. Informed selection of cell line(s) for a given...
Sep 5, 2017
Linc-ing Circulating Long Non-coding RNAs to the Diagnosis and Malignant Prediction of Intraductal Papillary Mucinous Neoplasms of the Pancreas
J. B. Permuth, D.-T. Chen, S. J. Yoder, J. Li, A. T. Smith, J. W. Choi, J. Kim, Y. Balagurunathan, K. Jiang, D. Coppola, B. A. Centeno, J. Klapman, P. Hodul, F. A. Karreth, J. G. Trevino, N. Merchant, A. Magliocco, M. P. Malafa, R. Gillies , Scientific Reports , DOI: 10.1038/s41598-017-09754-5
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that lacks effective biomarkers for early detection. We hypothesized that circulating long non-coding RNAs (lncRNAs) may act as diagnostic markers of incidentally-detected cystic PDAC precursors known as intraductal papillary mucinous neoplasms (IPMNs) and predictors of their pathology/histological classification. Using NanoString nCounter® technology,...
Sep 1, 2017
Automated detection of syncytial aggregates in digitized slide: comparison with pathologist's assessment
H. Pais, R. Shah, D. Roberts , C. Salafia , Placenta , DOI: 10.1016/j.placenta.2017.07.342
Objective: To develop an automated image analysis tool for the identification of the villous syncytium, and the quantitation of different histology features in digitized slides.Materials and Methods: Three high-resolution 2D images at 4x magnification were taken from one slide from each of the 90 placentas collected asa part of the...
Aug 25, 2017
Comprehensive Intrametastatic Immune Quantification and Major Impact of Immunoscore on Survival
B. Mlecnik, M. Van den Eynde, G. Bindea, S. E. Church, A. Vasaturo, T. Fredriksen, L. Lafontaine, N. Haicheur, F. Marliot, D. Debetancourt, G. Pairet, A. Jouret-Mourin, J.-F. Gigot, C. Hubert, E. Danse, C. Dragean J. Carrasco, Y. Humblet, V. Valge-Archer, A. Berger, F. Pagès, J.-P. Machiels, J. Galon , Journal of the National Cancer Institute , DOI: 10.1093/jnci/djx123
Background: This study assesses how the metastatic immune landscape is impacting the response to treatment and the outcome of colorectal cancer (CRC) patients.Methods: Complete curative resection of metastases (n = 441) was performed for two patient cohorts (n = 153). Immune densities were quantified in the center and invasive margin of all metastases. Immunoscore...