Feb 3, 2017
Imaging Mass Cytometry
Q. Chang, O. I. Ornatsky, I. Siddiqui, A. Loboda, V. I. Baranov, D. W. Hedley , Cytometry A , DOI:10.1002/cyto.a.23053
Imaging Mass Cytometry (IMC) is an expansion of mass cytometry, but rather than analyzing single cells in suspension, it uses laser ablation to generate plumes of particles that are carried to the mass cytometer by a stream of inert gas. Images reconstructed from tissue sections scanned by IMC have a...
Feb 2, 2017
Intravoxel incoherent motion MRI in the brain: Impact of the fitting model on perfusion fraction and lesion differentiability
V. C. Keil, B. Mädler, G. H. Gielen, B. Pintea, K. Hiththetiya, A. R. Gaspranova, J. Gieseke, M. Simon, H. H. Schild, D. R. Hadizadeh , Journal of magnetic resonance imaging , DOI: 10.1002/jmri.25615
Purpose: To investigate the effect of the choice of the curve-fitting model on the perfusion fraction (fIVIM ) with regard to tissue type characterization, correlation with microvascular anatomy, and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters. Several curve-fitting models coexist in intravoxel incoherent motion (IVIM) MRI to derive the (fIVIM...
Jan 20, 2017
Lab on a fabric: Mass producible and low-cost fabric filters for the high-throughput viable isolation of circulating tumor cells
J. Bua, Y.-T. Kanga, Y.-S. Leeb, J. Kimc, Y.-H. Choa, B.-I. Moond , Science Direct , DOI: 10.1016/j.bios.2017.01.039
Circulating tumor cells (CTCs) play an important role in estimating the presence and the metastatic relapse of tumor. Despite of their importance, isolation of viable CTCs is still struggling, since chemical or mechanical damages are unavoidable when separating less than 1000 of CTCs out of billions of other blood components....
Jan 20, 2017
iDermatoPath – A novel software tool for mitosis detection in H&E stained tissue sections of malignant melanoma
C. Andres, B. Andres-Belloni, R. Hein, T. Biedermann, A. Schäpe, N. Brieu, R. Schönmeyer, M. Yigitsoy, J. Ring, G. Schmidt, N. Harder , Journal of the European Academy of Dermatology and Venereology , DOI: 10.1111/jdv.14126
Background: Malignant Melanoma (MM) is characterized by a growing incidence and a high malignant potential. Beside well defined prognostic factors such as tumor thickness and ulceration, the Mitotic Rate (MR) was included in the AJCC recommendations for diagnosis and treatment of MM. In daily routine, the identification of a single...
Jan 17, 2017
Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1
A. S. Nagaraj, J. Lahtela, A. Hemmes, T. Pellinen, S. Blom, J. R. Devlin, K. Salmenkivi, O. Kallioniemi, M. I. Mäyränpää, K. Närhi, E. W. Verschuren , Cell Reports , DOI: 10.1016/j.celrep.2016.12.059
Lung cancers exhibit pronounced functional heterogeneity, confounding precision medicine. We studied how the cell of origin contributes to phenotypic heterogeneity following conditional expression of KrasG12D and loss of Lkb1 (Kras;Lkb1). Using progenitor cell-type-restricted adenoviral Cre to target cells expressing surfactant protein C (SPC) or club cell antigen 10 (CC10), we...