Dec 7, 2017
Mast Cell Density and Its Clinical Relevance in Waldenstrom's Macroglobulinemia
R. Lemal, S. Poulain, A. L. Pilon, L. Veronese, A. Tchirkov, B. Lebecque, J.-O. Bay, F. Charlotte, M. G. Berger, C. Godfraind, L. Ysebaert, F. Davi, V. Leblond, O. Hermine, R. Guieze, F. Pages, O. Tournilhac , Blood , Online ISSN: 1528-0020
Background: Waldenström's macroglobulinemia (WM) is characterized by a lymphoplasmacytic infiltration of the bone marrow (BM) along with a serum monoclonal IgM and includes MYD88 L265P and CXCR4 mutations in around 90% and 25% respectively (Treon, NEJM 2012; Hunter, Blood 2014). CXCR4 WHIMmutations confer worse outcome and are associated with larger...
Dec 4, 2017
Phase II prospective randomized trial of weight loss prior to radical prostatectomy
S. M. Henning, C. Galet, K. Gollapudi, J. B. Byrd, P. Liang, Z. Li, T. Grogan, D. Elashoff, C. E. Magyar, J. Said, P. Cohen, W. J. Aronson , Prostate Cancer and Prostatic Diseases , DOI:10.1038/s41391-017-0001-1
Background: Obesity is associated with poorly differentiated and advanced prostate cancer and increased mortality. In preclinical models, caloric restriction delays prostate cancer progression and prolongs survival. We sought to determine if weight loss (WL) in men with prostate cancer prior to radical prostatectomy affects tumor apoptosis and proliferation, and if...
Nov 23, 2017
Histological and MRI markers of white matter damage in focal epilepsy
F. Deleo, M. Thom, L. Concha, A. Bernasconi, B. C.Bernhardt, N. Bernasconi , Epilepsy Research , DOI: 10.1016/j.eplepsyres.2017.11.010
Growing evidence highlights the importance of white matter in the pathogenesis of focal epilepsy. Ex vivo and post-mortem studies show pathological changes in epileptic patients in white matter myelination, axonal integrity, and cellular composition. Diffusion-weighted MRI and its analytical extensions, particularly diffusion tensor imaging (DTI), have been the most widely...
Nov 22, 2017
Neurofilament distribution in the superior labrum and the long head of the biceps tendon
S. Boesmueller, A. Nógrádi, P. Heimel, C. Albrecht, S. Nürnberger, H. Redl, C. Fialka, R. Mittermayr , Journal of Orthopaedic Surgery and Research , DOI: 10.1186/s13018-017-0686-9
Background: The postoperative course after arthroscopic superior labrum anterior to posterior (SLAP) repair using suture anchors is accompanied by a prolonged period of pain, which might be caused by constriction of nerve fibres. The purpose was to histologically investigate the distribution of neurofilament in the superior labrum and the long...
Nov 16, 2017
Evaluation of Ki-67 Index in Core Needle Biopsies and Matched Breast Cancer Surgical Specimens
S. Ahn, J. Lee, M.-S. Cho, S. Park, S. H. Sung , Archives of Pathology & Laboratory Medicine , DOI: 10.5858/arpa.2017-0014-OA
Context: The Ki-67 index is strongly prognostic and is used as a surrogate marker to distinguish luminal A from luminal B breast cancer types.Objective: To investigate differences in Ki-67 index between core needle biopsy samples and matched surgical samples in breast cancer.Design: We included patients with invasive breast cancer who...