Nov 15, 2017
Characterization of neuroendocrine tumors in heterozygous mutant MENX rats: a novel model of invasive medullary thyroid carcinoma
S. Molatore, A. Kügler, M. Irmler, T. Wiedemann, F. Neff, A. Feuchtinger, J. Beckers, M. Robledo, F. Roncaroli, N. S. Pellegata , Society for Endocrinology , DOI: 10.1530/ERC-17-0456
Rats affected by the MENX syndrome spontaneously develop multiple neuroendocrine tumors (NETs) including adrenal, pituitary and thyroid gland neoplasms. MENX was initially reported to be inherited as a recessive trait and affected rats were found to be homozygous for the predisposing Cdkn1b mutation encoding p27. We here report that heterozygous...
Nov 15, 2017
In Silico Modeling of Immunotherapy and Stroma-Targeting Therapies in Human Colorectal Cancer
J. N. Kather, J. Poleszczuk, M. Suarez-Carmona, J. Krisam, P. Charoentong, N. A. Valous, C.-A. Weis, L. Tavernar, F. Leiss, E. Herpel, F. Klupp, A. Ulrich, M. Schneider, A. Marx, D. Jäger, N. Halama , Cancer Research , DOI: 10.1158/0008-5472.CAN-17-2006
Despite the fact that the local immunological microenvironment shapes the prognosis of colorectal cancer, immunotherapy has shown no benefit for the vast majority of colorectal cancer patients. A better understanding of the complex immunological interplay within the microenvironment is required. In this study, we utilized wet lab migration experiments and...
Nov 13, 2017
Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts
L. Bejarano, A. J. Schuhmacher, M. Méndez, D. Megías, C. Blanco-Aparicio, S. Martínez, J. Pastor, M. Squatrito, M. A. Blasco , Cancer Cell , DOI: 10.1016/j.ccell.2017.10.006
Glioblastoma multiforme (GBM) is a deadly and common brain tumor. Poor prognosis is linked to high proliferation and cell heterogeneity, including glioma stem cells (GSCs). Telomere genes are frequently mutated. The telomere binding protein TRF1 is essential for telomere protection, and for adult and pluripotent stem cells. Here, we find...
Nov 13, 2017
Image analysis is an excellent tool for quantifying Ki-67 to predict the prognosis of gastrointestinal stromal tumor patients
S. Sugita, H. Hirano, Y. Hatanaka, H. Fujita, T. Kubo, N. Kikuchi, Y. Ito, T. Sugawara, K. Segawa, H. Hisai, K. Yamashita, T. Nobuoka, Y. Matsuno, T. Hasegawa , Pathology International , DOI: 10.1111/pin.12611
We investigated the quantification of Ki-67 staining using digital image analysis (IA) as a complementary prognostic factor to the modified National Institutes of Health (NIH) classification in patients with gastrointestinal stromal tumor (GIST). We examined 92 patients, focusing on the correlation between age, sex, primary tumor site, tumor size, predominant...
Nov 10, 2017
Metabolic Profiling of healthy and cancerous tissues in 2D and 3D
S. Russell, J. Wojtkowiak, A. Neilson, R. J. Gillies , Scientific Reports , DOI: 10.1038/s41598-017-15325-5
Metabolism is a compartmentalized process, and it is apparent in studying cancer that tumors, like normal tissues, demonstrate metabolic cooperation between different cell types. Metabolic profiling of cells in 2D culture systems often fails to reflect the metabolism occurring within tissues in vivo due to lack of other cell types...