Aug 1, 2017
Exploiting Analysis of Heterogeneity to Increase the Information Content Extracted from Fluorescence Micrographs of Transgenic Zebrafish Embryos
T. Shun, A. H. Gough,S. Sanker, N. A. Hukriede, A. Vogt , ASSAY and Drug Development Technologies , DOI: 10.1089/adt.2017.793
Zebrafish embryos are a near-ideal animal model for drug discovery because of their high genetic and physiological similarity to mammals, small size, high fecundity, and optical transparency. The latter properties make zebrafish at larval stages especially suited for high-content analysis and high throughput screening (HTS). However, inherent biological complexity and...
Jul 29, 2017
Tumor microenvironment determines response to a heat-activated thermosensitive liposome formulation of cisplatin in cervical carcinoma
Y. N.Dou, N. Chaudary, M. C.Chang, M. Dunne, H. Huang, D. A.Jaffray, M. Milosevic, C. Allen , Journal of Controlled Release , DOI: 10.1016/j.jconrel.2017.07.039
Significant heterogeneity in the tumor microenvironment of human cervical cancer patients is known to challenge treatment outcomes in this population. The current standard of care for cervical cancer patients is radiation therapy and concurrent cisplatin (CDDP) chemotherapy. Yet this treatment strategy fails to control loco-regional disease in 10–30% of patients....
Jul 25, 2017
Intratumoural evolutionary landscape of high risk prostate cancer: The PROGENY study of genomic and immune parameters
M. Linch, G. Goh, C. Hiley, Y. Shanmugabavan, N. McGranahan, A. Rowan, Y.N.S. Wong, H. King, A. Furness, A. Freeman, J. Linares, A. Akarca, J. Herrero, R. Rosenthal, N. Harder, G. Schmidt, G.A. Wilson, N.J. Birkbak, R. Mitter, S. Dentro, P. Cathcart, M. Arya, E. Johnston, R. Scott, M. Hung, M. Emberton, G. Attard, Z. Szallasi, S. Punwani, S.A. Quezada, T. Marafioti, M. Gerlinger, H.U. Ahmed, C. Swanton , Annals of Oncology , DOI: 10.1093/annonc/mdx355
Background: Intratumoural heterogeneity (ITH) is well recognised in prostate cancer (PC) but its role in high-risk disease is uncertain. A prospective single arm translational study using targeted multiregion prostate biopsies was performed to study genomic and T-cell ITH in clinically high-risk PC aiming to identify drivers and potential therapeutic strategies.Patients...
Jul 23, 2017
Alveolar bone resorption after primary tooth loss has a negative impact on straightforward implant installation in patients with agenesis of the lower second premolar
K. Bertl, M. H. Bertl, P. Heimel, M. Burt, A. Gahleitner, A. Stavropoulos, C. Ulm , Clinical Oral Implants Research , DOI: 10.1111/clr.13033
Objectives: To compare the alveolar bone dimensions in patients with lower second premolar (P2) agenesis prior to and after primary molar loss on CT scans, and assess the possibility for straightforward implant placement.Methods: Alveolar bone dimensions were evaluated on 150 mandibular CT scans in three groups: (i) agenesis of P2,...
Jul 20, 2017
Enhanced Energetic State and Protection from Oxidative Stress in Human Myoblasts Overexpressing BMI1
S. Dibenedetto, M. Niklison-Chirou, C. P. Cabrera, M. Ellis, L.G. Robson, P. Knopp, F. S. Tedesco, M. Ragazzi, V. Di Foggia, M. R. Barnes, A. Radunovic, S. Marino , Stem Cell Reports , DOI: 10.1016/j.stemcr.2017.06.009
The Polycomb group gene BMI1 is essential for efficient muscle regeneration in a mouse model of Duchenne muscular dystrophy, and its enhanced expression in adult skeletal muscle satellite cells ameliorates the muscle strength in this model. Here, we show that the impact of mild BMI1 overexpression observed in mouse models...