May 2, 2017
Imaging features from pre-treatment CT scans are associated with clinical outcomes in non-small-cell lung cancer patients treated with stereotactic body radiotherapy
Q. Li, J. Kim, Y. Balagurunathan, Y. Liu, K. Latifi, O. Stringfield, A. Garcia, E. G. Moros, T.J. Dilling, M.B. Schabath, Z. Ye, R. J. Gillies , Medical Physics , DOI: 10.1002/mp.12309
Purpose: To investigate whether imaging features from pre-treatment planning CT scans are associated with overall survival (OS), recurrence-free survival (RFS), and loco-regional recurrence-free survival (LR-RFS) after stereotactic body radiotherapy (SBRT) among non-small-cell lung cancer (NSCLC) patients.Patients and methods: A total of 92 patients (median age: 73 years) with stage I...
May 1, 2017
Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions
P.M. Abdul-Muneera, S. Alikunju, V. Mishra, H. Schuetz, A. M. Szlachetka, E. L. Burnham, J. Haorah , Brain, Behavior, and Immunity , DOI: 10.1016/j.bbi.2017.02.014
Epidemiological studies showed a strong association between alcoholism and incidence of stroke, for which the underlying causative mechanisms remain to be understood. Here we found that infiltration of immune cells and deposition of cholesterol at the site of brain artery/capillary injury induced atherosclerosis in chronic alcohol (ethanol) consumption in the...
Apr 25, 2017
Image analysis of immune cell patterns in the human mammary gland during the menstrual cycle refines lymphocytic lobulitis
N. S. Schaadt, J. C. López Alfonso, R. Schönmeyer, A. Grote, G. Forestier, C. Wemmert, N. Krönke, M. Stoeckelhuber, H. H. Kreipe, H. Hatzikirou, F. Feuerhake , Breast Cancer Research and Treatment , DOI: 10.1007/s10549-017-4239-z
Purpose: To improve microscopic evaluation of immune cells relevant in breast cancer oncoimmunology, we aim at distinguishing normal infiltration patterns from lymphocytic lobulitis by advanced image analysis. We consider potential immune cell variations due to the menstrual cycle and oral contraceptives in non-neoplastic mammary gland tissue.Methods: Lymphocyte and macrophage distributions...
Apr 25, 2017
Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis
S. Lugert, T. Kremer, R. Jagasia, A. Herrmann, S. Aigner, C. Giachino, I. Mendez-David, A. M. Gardier, J. P. Carralot, H. Meistermann, A. Augustin, M. D. Saxe, J. Lamerz, G. Duran-Pacheco, A. Ducret, V. Taylor, D. J. David, C. Czech , Scientific Reports , DOI: 10.1038/srep46543
Adult hippocampal neurogenesis is a remarkable form of brain plasticity through which new neurons are generated throughout life. Despite its important roles in cognition and emotion and its modulation in various preclinical disease models, the functional importance of adult hippocampal neurogenesis in human health has not been revealed because of...
Apr 25, 2017
Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R
J. K. Mitchell, B. R. Midkiff, B. Israelow, M. J. Evans, R. E. Lanford, C. M. Walker, S. M. Lemon, D. R. McGivern , mBio , DOI: 10.1128/mBio.00121-17
Many DNA tumor viruses promote cellular transformation by inactivating the critically important tumor suppressor protein p53. In contrast, it is not known whether p53 function is disrupted by hepatitis C virus (HCV), a unique, oncogenic RNA virus that is the leading infectious cause of liver cancer in many regions of...