Aug 24, 2017
The Natural Fungal Metabolite Beauvericin Exerts Anticancer Activity In Vivo: A Pre-Clinical Pilot Study
D. Heilos, Y. Rodríguez-Carrasco, B. Englinger, G. Timelthaler, S. van Schoonhoven, M. Sulyok, S. Boecker, R. D. Süssmuth, P. Heffeter, R. Lemmens-Gruber, R. Dornetshuber-Fleiss, W. Berger , Toxins , DOI: 10.3390/toxins9090258
Recently, in vitro anti-cancer properties of beauvericin, a fungal metabolite were shown in various cancer cell lines. In this study, we assessed the specificity of this effect by comparing beauvericin cytotoxicity in malignant versus non-malignant cells. Moreover, we tested in vivo anticancer effects of beauvericin by treating BALB/c and CB-17/SCID...
Aug 22, 2017
Human Pancreatic Tumors Grown in Mice Release Tissue Factor-positive Microvesicles that Increase Venous Clot Size
Y. Hisada, C. Ay, A.C. Auriemma, B.C. Cooley, N. Mackman , Journal of Thrombosis and Haemostatis , DOI: 10.1111/jth.13809
Background: Pancreatic cancer patients have a high rate of venous thromboembolism. Human pancreatic tumors and cell lines express high levels of tissue factor (TF) and release TF-positive microvesicles (TF+MVs). In pancreatic cancer patients, tumor-derived TF+MVs are present in blood and increased levels are associated with venous thromboembolism and decreased survival....
Aug 21, 2017
Treg depletion potentiates checkpoint inhibition in claudin-low breast cancer
N. A. Taylor, S. C. Vick, M. D. Iglesia, W. J. Brickey, B. R. Midkiff, K. P. McKinnon, S. Reisdorf, C. K. Anders, L. A. Carey, J. S. Parker, C. M. Perou, B. G. Vincent, J. S. Serody , The Journal of Clinical Investigation , DOI:10.1172/JCI90499
Claudin-low breast cancer is an aggressive subtype that confers poor prognosis and is found largely within the clinical triple-negative group of breast cancer patients. Here, we have shown that intrinsic and immune cell gene signatures distinguish the claudin-low subtype clinically as well as in mouse models of other breast cancer...
Aug 18, 2017
Impaired periodontium and temporomandibular joints in TNF-α transgenic mice
T. Dobsak, P. Heimel, S. Tangl, U. Schwarze, G. Schett, R. Gruber , Journal of Clinical Periodontology , DOI: 10.1111/jcpe.12799
Aim: TNF-α is a pathological factor causing the characteristic symptoms of periodontal disease and rheumatoid arthritis. In this study we describe the phenotypes of human tumor necrosis factor (TNF)-α transgenic mice (hTNFtg) with respect to their periodontium and the temporomandibular joint (TMJ).Material and methods: Periodontal structures, TMJ, and skull shape...
Aug 17, 2017
Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever
M. M. Remy, M. Sahin, L. Flatz, T. Regen, L. Xu, M. Kreutzfeldt, B. Fallet, C. Doras, T. Rieger, L. Bestmann, U.-K. Hanisch, B. A. Kaufmann, D. Merkler, D. D. Pinschewer , Cell Host & Microbe , DOI: 10.1016/j.chom.2017.07.008
Arenaviruses such as Lassa virus (LASV) cause hemorrhagic fever. Terminal shock is associated with a systemic cytokine storm, but the mechanisms are ill defined. Here we used HLA-A2-expressing mice infected with a monkey-pathogenic strain of lymphocytic choriomeningitis virus (LCMV-WE), a close relative of LASV, to investigate the pathophysiology of arenavirus...