Jun 21, 2017
WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death
M. M. Fischer, B. Cancilla, V. P. Yeung, F. Cattaruzza, C. Chartier, C. L. Murriel, J. Cain, R. Tam, C.-Y. Cheng, J. W. Evans, G. O’Young, X. Song, J. Lewicki, A. M. Kapoun, A. Gurney, W.-C. Yen, T. Hoey , Sciences Advances , DOI: 10.1126/sciadv.1700090
The WNT pathway mediates intercellular signaling that regulates cell fate in both normal development and cancer. It is widely appreciated that the WNT pathway is frequently dysregulated in human cancers through a variety of genetic and epigenetic mechanisms. Targets in the WNT pathway are being extensively pursued for the development...
Jun 20, 2017
Antitumor activity of indenoisoquinoline inhibitors of topoisomerase 1 (TOP1) via apoptosis and autophagocytosis pathways in animal models.
R. J. Kinders, A. B. Dull, D. Wilsker, A. LeBlanc, C. Mazcko, M. G. Hollingshead, R. E. Parchment, J. H. Doroshow , Journal of Clinical Oncology , DOI: 10.1200/JCO.2017.35.15_suppl.11588
Background: We performed pharmacodynamic biomarker analysis for response to a panel of three indenoisoquinolines (LMP776, LMP400 and NSC706744, J. Med. Chem. 49:7740, 2006) that have demonstrated anti-tumor activity in dogs. In preclinical xenograft models treated with indenoisoquinolines, we observed that gH2AX was not a useful biomarker for the biological activity...
Jun 19, 2017
Learning size adaptive local maxima selection for robust nuclei detection in histopathology images
N. Brieu, G. Schmidt , 2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017) , DOI: 10.1109/ISBI.2017.7950670
The detection of cells and nuclei is a crucial step for the automatic analysis of digital pathology slides and as such for the quantification of the phenotypic information contained in tissue sections. This task is however challenging because of high variability in size, shape and textural appearance of the objects...
Jun 15, 2017
Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation
K. Tech, A. P. Tikunov, H. Farooq, A. S. Morrissy, J. Meidinger, T. Fish, S. C. Green, H. Liu, Y. Li, A. J. Mungall, R. A. Moore, Y. Ma, S. J.M. Jones, M. A. Marra, M. G. Vander Heiden, M. D. Taylor, J. M. Macdonald, T. R. Gershon , Cancer Research , DOI: 10.1158/0008-5472.CAN-16-3304
Aerobic glycolysis supports proliferation through unresolved mechanisms. We have previously shown that aerobic glycolysis is required for the regulated proliferation of cerebellar granule neuron progenitors (CGNP) and for the growth of CGNP-derived medulloblastoma. Blocking the initiation of glycolysis via deletion of hexokinase-2 (Hk2) disrupts CGNP proliferation and restricts medulloblastoma growth....
Jun 14, 2017
Advanced Image Analysis of Stem Cells and Tumor Initiating Cells
B. Laffin, J. Zimmermann , MedCrave , DOI: 10.15406/jsrt.2017.02.00085
Digital pathology and image analysis studies are growing rapidly in prevalence and sophistication, due to advances in multiplexed immunohistochemical techniques, whole slide imaging of tissue, and dealing with the complexities of personalized medicine. Oncology in particular has seen large investment in image analysis as a way to identify those patients...