Nov 16, 2016
A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human...
A. R. Iskandar, C. Mathis, W. K. Schlage, S. Frentzel, P. Leroy, Y. Xiang, A. Sewer, S. Majeed, L. Ortega-Torres, S. Johne, E. Guedj, K. Trivedi, G. Kratzer, C. Merg, A. Elamin, F. Martin, N. V. Ivanov, M. C. Peitsch, J. Hoeng , Toxicology in Vitro , DOI: 10.1016/j.tiv.2016.11.009
This study reports a comparative assessment of the biological impact of a heated tobacco aerosol from the tobacco heating system (THS) 2.2 and smoke from a combustible 3R4F cigarette. Human organotypic bronchial epithelial cultures were exposed to an aerosol from THS2.2 (a candidate modified-risk tobacco product) or 3R4F smoke at...
Nov 16, 2016
Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model
E. Romanelli, D. Merkler, A. Mezydlo, M.-T. Weil, Martin S. Weber, I. Nikić, S. Potz, E. Meinl, F. E. H. Matznick, M. Kreutzfeldt, A. Ghanem, K.-K. Conzelmann, I. Metz, W. Brück, M. Routh, M. Simons, D. Bishop, T. Misgeld, M. Kerschensteiner , nature communications , DOI: 10.1038/ncomms13275
Oligodendrocyte damage is a central event in the pathogenesis of the common neuroinflammatory condition, multiple sclerosis (MS). Where and how oligodendrocyte damage is initiated in MS is not completely understood. Here, we use a combination of light and electron microscopy techniques to provide a dynamic and highly resolved view of...
Nov 14, 2016
Integrin-Targeted hybrid Fluorescence Molecular Tomography/X-ray Computed Tomography for Imaging Tumor Progression and Early Response in Non-Small Cell Lung Cancer
X. Ma, V. Phi Van, M. A. Kimm, J. Prakash, H. Kessler, K. Kosanke, A. Feuchtinger, M. Aichler, A. Gupta, E. J. Rummeny, M. Eisenblätter, J. Siveke, A. K. Walch, R. Braren, V. Ntziachristos, M. Wildgruber , Neoplasia , DOI: 10.1016/j.neo.2016.11.009
Integrins play an important role in tumor progression, invasion and metastasis. Therefore we aimed to evaluate a preclinical imaging approach applying ανβ3 integrin targeted hybrid Fluorescence Molecular Tomography/X-ray Computed Tomography (FMT-XCT) for monitoring tumor progression as well as early therapy response in a syngeneic murine Non-Small Cell Lung Cancer (NSCLC)...
Nov 13, 2016
Combinatorial CD8+ and PD-L1+ cell densities correlate with response and improved survival in non-small cell lung cancer (NSCLC) patients treated with durvalumab
S. Althammer, K. Steele, M. Rebelatto, T. H. Tan, T. Wiestler, G. Schmidt, B. Higgs, X. Li, L. Shi, X. Jin, J. Antal, A. Gupta, K. Ranade, G. Binning , Journal for ImmunoTherapy of Cancer , DOI 10.1186/s40425-016-0191-4
Background: Immunotherapies have improved patient responses and survival, though not all patients benefit. Effective biomarkers may help to improve outcomes. Durvalumab is a human IgG1 monoclonal antibody that inhibits PD-L1 binding to PD-1 and CD80, restoring antitumor immunity [1, 2]. PD-L1 expression on tumor or tumor-infiltrating immune cells measured manually...
Nov 10, 2016
Persistent Microvascular Obstruction After Myocardial Infarction Culminates in the Confluence of Ferric Iron Oxide Crystals, Proinflammatory Burden, and Adverse Remodeling
A. Kali, I. Cokic, R. Tang, A. Dohnalkova, L. Kovarik, H.-J. Yang, A. Kumar, F. S. Prato, J. C. Wood, D. Underhill, E. Marbán, R. Dharmakumar , Circulation: Cardiovascular Imaging , DOI: 10.1161/CIRCIMAGING.115.004996
Background: Emerging evidence indicates that persistent microvascular obstruction (PMO) is more predictive of major adverse cardiovascular events than myocardial infarct (MI) size. But it remains unclear how PMO, a phenomenon limited to the acute/subacute period of MI, drives adverse remodeling in chronic MI setting. We hypothesized that PMO resolves into...