Oct 13, 2014
Differential effects of targeting Notch receptors in a mouse model of liver cancer
E. G. Huntzicker, K. Hötzel, L. Choy, L. Che, J. Ross, G. Pau, N. Sharma, C.W. Siebel, X. Chen, D. M. French , Hepathology , DOI: 10.1002/hep.27566
Primary liver cancer encompasses both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). The Notch signaling pathway, known to be important for the proper development of liver architecture, is also a potential driver of primary liver cancer. However, with four known Notch receptors and several Notch ligands, it is not clear which...
Oct 7, 2014
Translational research in oncology-10 years of progress and future prospects
J. H. Doroshow, S. Kummar , Nature Reviews. Clinical Oncology , DOI: 10.1038/nrclinonc.2014.158
International efforts to sequence the genomes of various human cancers have been broadly deployed in drug discovery programmes. Diagnostic tests that predict the value of the molecularly targeted anticancer agents used in such programmes are conceived and validated in parallel with new small-molecule treatments and immunotherapies. This approach has been...
Oct 6, 2014
CLIP2 as radiation biomarker in papillary thyroid carcinoma
Selmansberger M, Feuchtinger A, Zurnadzhy L, Michna A, Kaiser JC, Abend M, Brenner A, Bogdanova T, Walch A, Unger K, Zitzelsberger H, Hess J , Oncogene , DOI: 10.1038/onc.2014.311
A substantial increase in papillary thyroid carcinoma (PTC) among children exposed to the radioiodine fallout has been one of the main consequences of the Chernobyl reactor accident. Recently, the investigation of PTCs from a cohort of young patients exposed to the post-Chernobyl radioiodine fallout at very young age and a...
Sep 9, 2014
Interleukin-like epithelial-to-mesenchymal transition inducer activity is controlled by proteolytic processing and plasminogen–urokinase plasminogen activator receptor system–regulated secretion...
A. Csiszar, B. Kutay, S. Wirth, U. Schmidt, S. Macho-Maschler, M. Schreiber, M. Alacakaptan, G. F. Vogel, K. Aumayr, L. A. Huber, H. Beug , Breast Cancer Research , DOI: 10.1186/s13058-014-0433-7
Introduction: Interleukin-like epithelial-to-mesenchymal transition inducer (ILEI) is an essential cytokine in tumor progression that is upregulated in several cancers, and its altered subcellular localization is a predictor of poor survival in human breast cancer. However, the regulation of ILEI activity and the molecular meaning of its altered localization remain elusive.Methods:...
Sep 1, 2014
Theranostic USPIO-Loaded Microbubbles for Mediating and Monitoring Blood-Brain Barrier Permeation
T. Lammers, P. Koczera, S. Fokong, F. Gremse, J. Ehling, M. Vogt, A. Pich, G. Storm, M. van Zandvoort, F. Kiessling , Advanced Functional Materials , DOI: 10.1002/adfm.201401199
Efficient and safe drug delivery across the blood-brain barrier (BBB) remains one of the major challenges of biomedical and (nano-) pharmaceutical research. Here, it is demonstrated that poly(butyl cyanoacrylate)-based microbubbles (MB), carrying ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles within their shell, can be used to mediate and monitor BBB permeation....