Mar 23, 2011
The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression
D. Schramek, A. Kotsinas, A. Meixner, T. Wada, U. Elling, J.A. Pospisilik, G. G. Neely, R. H. Zwick, V. Sigl, G. Forni, M. Serrano, V. G. Gorgoulis, J. M. Penninger , Nature Genetics , DOI: 10.1038/ng.767
Most preneoplastic lesions are quiescent and do not progress to form overt tumors. It has been proposed that oncogenic stress activates the DNA damage response and the key tumor suppressor p53, which prohibits tumor growth. However, the molecular pathways by which cells sense a premalignant state in vivo are largely...
Mar 3, 2011
Cytosolic phospholipase A2α gene silencing in the myeloid lineage alters development of Th1 responses and reduces disease severity in collagen-induced arthritis
Courties G, Baron M, Presumey J, Escriou V, van Lent P, Scherman D, Cantagrel A, van den Berg WB, Jorgensen C, Apparailly F, Davignon JL , Arthritis Rheum , Volume 63, Issue 3, pp. 681-90
Several lines of evidence implicate cytosolic phospholipase A(2)α (cPLA(2)α) as a critical enzyme in inflammatory disorders, including rheumatoid arthritis. Since cells from the myeloid compartment regulate local and systemic disease pathogenesis, the present study was undertaken to examine the effect of cPLA(2)α inhibition in experimental arthritis, using a delivery system...
Jan 12, 2011
OPA1 links human mitochondrial genome maintenance to mtDNA replication and distribution
Elachouri G, Vidoni S, Zanna C, Pattyn A, Boukhaddaoui H, Gaget K, Yu-Wai-Man P, Gasparre G, Sarzi E, Delettre C, Olichon A, Loiseau D, Reynier P, Chinnery PF, Rotig A, Carelli V, Hamel CP, Rugolo M, Lenaers G , Genome Res , Volume 21, Issue 1, pp. 12-20
Eukaryotic cells harbor a small multiploid mitochondrial genome, organized in nucleoids spread within the mitochondrial network. Maintenance and distribution of mitochondrial DNA (mtDNA) are essential for energy metabolism, mitochondrial lineage in primordial germ cells, and to prevent mtDNA instability, which leads to many debilitating human diseases. Mounting evidence suggests that...
Dec 27, 2010
SIRT1 contributes to telomere maintenance and augments global homologous recombination
Palacios J, Herranz D, De Bonis M, Velasco S, Serrano M, Blasco M , The Journal of Cell Biology , volume 191, issue 7, pp. 1299 - 1313
Yeast Sir2 deacetylase is a component of the silent information regulator (SIR) complex encompassing Sir2/Sir3/Sir4. Sir2 is recruited to telomeres through Rap1, and this complex spreads into subtelomeric DNA via histone deacetylation. However, potential functions at telomeres for SIRT1, the mammalian orthologue of yeast Sir2, are less clear. We studied...
Nov 24, 2010
Sororin mediates sister chromatid cohesion by antagonizing Wapl.
T. Nishiyama, R. Ladurner, J. Schmitz, E. Kreidl, A. Schleiffer, V. Bhaskara, M. Bando, K. Shirahige, A. A. Hyman, K. Mechtler, J. M. Peters , Cell , DOI: 10.1016/j.cell.2010.10.031
Sister chromatid cohesion is essential for chromosome segregation and is mediated by cohesin bound to DNA. Cohesin-DNA interactions can be reversed by the cohesion-associated protein Wapl, whereas a stably DNA-bound form of cohesin is thought to mediate cohesion. In vertebrates, Sororin is essential for cohesion and stable cohesin-DNA interactions, but...