Jan 11, 2016
Osteoprotegerin Regulates Pancreatic β-Cell Homeostasis upon Microbial Invasion
Y. Kuroda, K. Maruyama, H. Fujii, I. Sugawara, S. B. H. Ko, H. Yasuda, H. Matsui, K. Matsuo , PLoS ONE , DOI: 10.1371/journal.pone.0146544
Osteoprotegerin (OPG), a decoy receptor for receptor activator of NF-κB ligand (RANKL), antagonizes RANKL’s osteoclastogenic function in bone.We previously demonstrated that systemic administration of lipopolysaccharide (LPS) to mice elevates OPG levels and reduces RANKL levels in peripheral blood. Here, we show that mice infected with Salmonella, Staphylococcus, Mycobacteria or influenza...
Jan 8, 2016
Increased peri-ductal collagen micro-organization may contribute to raised mammographic density
J. C. McConnell, O. V. O’Connell, K. Brennan, L. Weiping, M. Howe, L. Joseph, D. Knight, R. O’Cualain, Y. Lim, A. Leek, R. Waddington, J. Rogan, S. M. Astley, A. Gandhi, C. C. Kirwan, M. J. Sherratt, C. H. Streuli , Breast Cancer Research , DOI: 10.1186/s13058-015-0664-2
Background: High mammographic density is a therapeutically modifiable risk factor for breast cancer. Although mammographic density is correlated with the relative abundance of collagen-rich fibroglandular tissue, the causative mechanisms, associated structural remodelling and mechanical consequences remain poorly defined. In this study we have developed a new collaborative bedside-to-bench workflow to...
Jan 8, 2016
Fast synthesis and bioconjugation of (68) Ga core-doped extremely small iron oxide nanoparticles for PET/MR imaging
J. Pellico, J. Ruiz-Cabello, M. Saiz-Alía, G. Del Rosario, S. Caja, M. Montoya, L. Fernández de Manuel, M.P. Morales, L. Gutiérrez, B. Galiana, J.A. Enríquez, F. Herranz , Contrast Media & Molecular Imaging , DOI: 10.1002/cmmi.1681
Combination of complementary imaging techniques, like hybrid PET/MRI, allows protocols to be developed that exploit the best features of both. In order to get the best of these combinations the use of dual probes is highly desirable. On this sense the combination of biocompatible iron oxide nanoparticles and 68Ga isotope...
Jan 8, 2016
Histopathological image analysis of chemical-induced hepatocellular hypertrophy in mice
Y. Asaokaa, Y. Togashia, M. Mutsugaa, N. Imuraa, T. Miyoshia, Y. Miyamotob , Experimental and Toxicologic Pathology , DOI: 10.1016/j.etp.2015.12.005
Chemical-induced hepatocellular hypertrophy is frequently observed in rodents, and is mostly caused by the induction of phase I and phase II drug metabolic enzymes and peroxisomal lipid metabolic enzymes. Liver weight is a sensitive and commonly used marker for detecting hepatocellular hypertrophy, but is also increased by a number of...
Jan 6, 2016
Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line
M. Schmitt, B. Dehay, E. Bezard, F. J. Garcia-Ladona , Synapse , DOI: 10.1002/syn.21881
The identification of an effective disease-modifying treatment for the neurodegenerative progression in Parkinson's disease (PD) remains a major challenge. Epidemiological studies have reported that intake of statins, cholesterol lowering drugs, could be associated to a reduced risk of developing PD. In-vivo studies suggest that statins may reduce the severity of...