Jul 25, 2013
Rapamycin extends murine lifespan but has limited effects on aging
F. Neff, D. Flores-Dominguez, D. P. Ryan, M. Horsch, S. Schröder, T. Adler, L. C. Afonso, J. A. Aguilar-Pimentel, L. Becker, L. Garrett, W. Hans, M. M. Hettich, R. Holtmeier, S. M. Hölter, K. Moreth, C. Prehn, O. Puk, I. Rácz, B. Rathkolb, J. Rozman, B. Naton, R. Ordemann, J. Adamski, J. Beckers, R. Bekeredjian, D. H. Busch, G. Ehninger, J. Graw, H. Höfler, M. Klingenspor, T. Klopstock, M. Ollert, J. Stypmann, E. Wolf, W. Wurst, A. Zimmer, H. Fuchs, V. Gailus-Durner, M. Hrabe de Angelis, D. Ehninger , The Journal of Clinical Investigation , DOI: 10.1172/JCI67674
Aging is a major risk factor for a large number of disorders and functional impairments. Therapeutic targeting of the aging process may therefore represent an innovative strategy in the quest for novel and broadly effective treatments against age-related diseases. The recent report of lifespan extension in mice treated with the...
Jul 2, 2013
Primary Cilia Are Lost in Preinvasive and Invasive Prostate Cancer
N. B. Hassounah, R. Nagle, K. Saboda, D. J. Roe, B. L. Dalkin, K. M. McDermott , PLoS ONE , DOI: 10.1371/journal.pone.0068521
Prostate cancer is the second most commonly diagnosed cancer in men worldwide. Little is known about the role of primary cilia in preinvasive and invasive prostate cancer. However, reduced cilia expression has been observed in human cancers including pancreatic cancer, renal cell carcinoma, breast cancer, cholangiocarcinoma, and melanoma. The aim...
Jun 20, 2013
Cryptopatches Are Essential for the Development of Human GALT
Nochi T, Denton PW, Wahl A, Garcia JV , Nochi T, Denton PW, Wahl A, Garcia JV , DOI: 10.1016/j.celrep.2013.05.037
Abnormal gut-associated lymphoid tissue (GALT) in humans is associated with infectious and autoimmune diseases, which cause dysfunction of the gastrointestinal (GI) tract immune system. To aid in investigating GALT pathologies in vivo, we bioengineered a human-mouse chimeric model characterized by the development of human GALT structures originating in mouse cryptopatches....
Jun 19, 2013
RAP1 Protects from Obesity through Its Extratelomeric Role Regulating Gene Expression
Martínez P, Gómez-López G, García F, Mercken E, Mitchell S, Flores JM, de Cabo R, Blasco MA , Cell Reports , DOI: 10.1016/j.celrep.2013.05.030
RAP1 is part of shelterin, the protective complex at telomeres. RAP1 also binds along chromosome arms, where it is proposed to regulate gene expression. To investigate the nontelomeric roles of RAP1 in vivo, we generated a RAP1 whole-body knockout mouse. These mice show early onset of obesity, which is more...
Jun 5, 2013
TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells
Schneider RP, Garrobo I, Foronda M, Palacios JA, Marión RM, Flores I, Ortega S, Blasco MA , Nature Communications , DOI: 10.1038/ncomms2946
TRF1 is a component of the shelterin complex that protects chromosome ends. TRF1 deficiency leads to early embryonic lethality and to severe organ atrophy when deleted in adult tissues. Here we generate a reporter mouse carrying a knock-in eGFP-TRF1 fusion allele to study the role of TRF1 in stem cell...