Feb 29, 2016
Retinoid and carotenoid status in serum and liver among patients at high-risk for liver cancer
Y. Kataria,R. J. Deaton, E. Enk, M. Jin, M. Petrauskaite, L. Dong, J. R. Goldenberg, S. J. Cotler, D. M. Jensen, R. B. van Breemen, P. H. Gann , BMC Gastroenterology , DOI: 10.1186/s12876-016-0432-5
Background: Approximately 2.7 million Americans are chronically infected with hepatitis C virus (HCV). HCV patients with cirrhosis form the largest group of persons at high risk for hepatocellular carcinoma (HCC). Increased oxidative stress is regarded as a major mechanism of HCV-related liver disease progression. Deficiencies in retinoid and carotenoid antioxidants...
Feb 25, 2016
In Epstein–Barr virus-associated gastric carcinoma a high density of CD66b-positive tumor-associated neutrophils is associated with intestinal-type histology and low frequency of lymph node metastasis
H. Abe, T. Morikawa, R. Saito, H. Yamashita, Y. Seto, M. Fukayama , Virchows Archiv , DOI: 10.1007/s00428-016-1915-z
Epstein–Barr virus-associated gastric carcinoma (EBVaGC) is characterized by prominent intratumoral lymphocyte infiltration, with some infiltration by other types of inflammatory cells, such as neutrophils. In this study, the significance of tumor-associated neutrophils (TANs) and cytotoxic T lymphocytes (CTLs) was investigated in EBVaGC. CD66b-positive TANs and CD8-positive CTLs in surgically resected...
Feb 23, 2016
Utility of ATRX immunohistochemistry in diagnosis of adult diffuse gliomas
M. Ikemura, J. Shibahara, A. Mukasa, S. Takayanagi, K. Aihara, N. Saito, H. Aburatani, M. Fukayama , Histopathology , DOI: 10.1111/his.12927
AIMS: We performed an immunohistochemical analysis of alpha-thalassaemia/mental retardation syndrome X-linked (ATRX) expression in adult diffuse gliomas, with reference to clinicopathological and genetic features, to determine the utility of this analysis in diagnostic practice.METHODS AND RESULTS: A total of 193 adult diffuse gliomas underwent immunohistochemical analysis. In areas in which...
Feb 22, 2016
Telomerase gene therapy rescues telomere length, bone marrow aplasia and survival in mice with aplastic anemia
C. Bär, J. M. Povedano, R. Serrano, C. Benitez-Buelga, M. Popkes, I. Formentini, M. Bobadilla, F. Bosch, M. A. Blasco , Blood , DOI: 10.1182/blood-2015-08-667485
Aplastic anemia is a fatal bone marrow disorder characterized by peripheral pancytopenia and marrow hypoplasia. The disease can be hereditary or acquired and develops at any stage of life. A subgroup of the inherited form is caused by replicative impairment of hematopoietic stem and progenitor cells owing to very short...
Feb 16, 2016
Radiomic features are associated with EGFR mutation status in lung adenocarcinomas
Y. Liu, J. Kim, Y. Balagurunathan, Q. Li, A. L. Garcia, O. Stringfield, Z. Ye, R. J. Gillies , Clinical Lung Cancer , DOI: 10.1016/j.cllc.2016.02.001
Background: In this study we retrospectively evaluated the capability of computed tomography (CT)-based radiomic features to predict epidermal growth factor receptor (EGFR) mutation status in surgically-resected peripheral lung adenocarcinomas in an Asian cohort of patients.Patients and Methods:Two hundred ninety-eight patients with surgically resected peripheral lung adenocarcinomas were investigated in this...