Mar 22, 2013
Combat or Surveillance? Evaluation of the Heterogeneous Inflammatory Breast Cancer Microenvironment
Krüger JM, Wemmert C, Sternberger L, Bonnas C, Dietmann G, Gançarski P, Feuerhake F , J Pathol , DOI: 10.1002/path.4150
Evaluation of specific lymphocyte subsets is important in understanding the microenvironment in cancer and holds promise as prognostic parameter in invasive breast cancer. To address this we used digital image analysis to integrate cell abundance, distance metrics, neighbourhood relationships, and sample heterogeneity into comprehensive assessment of immune infiltrates. Lymphocyte and...
Mar 1, 2013
Longitudinal Expression Analysis of αv Integrins in Human Gliomas Reveals Upregulation of Integrin αvβ3 as a Negative Prognostic Factor
J. Schittenhelm, E. I. Schwab, J. Sperveslage, M. Tatagiba, R. Meyermann, F. Fend, S. L. Goodman, B. Sipos , Journal of Neuropathology & Experimental Neurology , DOI: 10.1097/NEN.0b013e3182851019
Integrin inhibitors targeting αv series integrins are being tested for their therapeutic potential in patients with brain tumors, but pathologic studies have been limited by lack of antibodies suitable for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded specimens. We compared the expression of αv integrins by IHC in brain tumor and normal...
Feb 28, 2013
High Heregulin Expression Is Associated with Activated HER3 and May Define an Actionable Biomarker in Patients with Squamous Cell Carcinomas of the Head and Neck
D. S. Shames, J. Carbon, K. Walter, A. M. Jubb, C. Kozlowski, T. Januario, D. An, L. Fu, Y. Xiao, R. Raja, B. Jiang, A. Malekafzali, H. Stern, J. Settleman, T. R. Wilson, G. M. Hampton, R. L. Yauch, A. Pirzkall , L. C. Amler , PLoS ONE , DOI: 10.1371/journal.pone.0056765
Purpose: Tumors with oncogenic dependencies on the HER family of receptor tyrosine kinases (RTKs) often respond well to targeted inhibition. Our previous work suggested that many cell lines derived from squamous cell carcinomas of the head and neck (SCCHNs) depend on autocrine signaling driven by HER2/3 dimerization and high-level co-expression...
Feb 28, 2013
Vascular E-Selectin Expression Correlates with CD8 Lymphocyte Infiltration and Improved Outcome in Merkel Cell Carcinoma
O. K. Afanasiev, K. Nagase, W. Simonson, N. Vandeven, A. Blom, D. M. Koelle, R. Clark, P. Nghiem , Journal of Investigative Dermatology , DOI: 10.1038/jid.2013.36
Merkel cell carcinoma (MCC) is an aggressive, polyomavirus-linked skin cancer. Although CD8 lymphocyte infiltration into the tumor is strongly correlated with improved survival, these cells are absent or sparse in most MCCs. We investigated whether specific mechanisms of T-cell migration may be commonly disrupted in MCC tumors with poor CD8...
Feb 11, 2013
LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin
D. B. Shackelford, E. Abt, L. Gerken, D. S. Vasquez, A. Seki, M. Leblanc, L. Wei, M. C. Fishbein, J. Czernin, P. S. Mischel, R. J. Shaw , Cancer Cell , DOI: 10.1016/j.ccr.2012.12.008
The LKB1 (also called STK11) tumor suppressor is mutationally inactivated in ∼20% of non-small cell lung cancers (NSCLC). LKB1 is the major upstream kinase activating the energy-sensing kinase AMPK, making LKB1-deficient cells unable to appropriately sense metabolic stress. We tested the therapeutic potential of metabolic drugs in NSCLC and identified...