Mar 26, 2015
Chronic replicative stress induced by CCl4 in TRF1 knockout mice recapitulates the origin of large liver cell changes
F. Beier, P. Martinez, M. A. Blasco , Journal of Hepathology , DOI: 10.1016/j.jhep.2015.03.022
Background & Aims: Large liver cell changes (LLCC) are characterized by pleomorphic large nuclei frequently found in liver diseases as chronic viral hepatitis and liver cirrhosis. The origin of this lesion remains cryptic, but the presence of LLCC is correlated with an increased risk of hepatocellular carcinoma. Telomeric repeat binding...
Mar 16, 2015
Clinical and Molecular Implications of MED15 in Head and Neck Squamous Cell Carcinoma
Z. Shaikhibrahim, A. Offermann, R. Halbach, W. Vogel, M. Braun, G. Kristiansen, F. Bootz, J. Wenzel, R. Mikut, C. Lengerke, M. Reischl, A. Schröck, S. Perner , The American Journal of Pathology , DOI: 10.1016/j.ajpath.2014.12.010
Head and neck squamous cell carcinoma (HNSCC) progression depends on various dysregulated pathways. Regulation of diverse pathways is mediated by the mediator complex. The mediator subunit MED15 is essential for transforming growth factor (TGF)-β signaling and involved in breast and prostate cancers. We investigated the implication of MED15 in HNSCC....
Mar 3, 2015
CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy
J. Escamilla, S. Schokrpur, C. Liu, S. J. Priceman, D. Moughon, Z. Jiang, F. Pouliot, C. Magyar, J. L. Sung, J. Xu, G. Deng, B. L. West, G. Bollag, Y. Fradet, L. Lacombe, M. E. Jung, J. Huang, L. Wu , Cancer Research , DOI: 10.1158/0008-5472.CAN-14-0992
Growing evidence suggests that tumor-associated macrophages (TAM) promote cancer progression and therapeutic resistance by enhancing angiogenesis, matrix-remodeling, and immunosuppression. In this study, prostate cancer under androgen blockade therapy (ABT) was investigated, demonstrating that TAMs contribute to prostate cancer disease recurrence through paracrine signaling processes. ABT induced the tumor cells to...
Feb 25, 2015
Automated Whole Slide Analysis of Differently Stained and Co-Registered Tissue Sections
R. Schönmeyer, N. Brieu, N. Schaadt, F. Feuerhake, G. Schmidt, G. Binnig , SpringerLink , DOI: 10.1007/978-3-662-46224-9_70
Digital pathology enables applications that are not possible using traditional microscopy and facilitates new ways of handling and presenting whole slide image data, along with quantitative evaluation. Differently stained tissue, highlighting specific biological functions, contains a vast amount of spatial information that must be interpreted by a pathologist. With automated...
Feb 19, 2015
NFAT1 promotes intratumoral neutrophil infiltration by regulating IL8 expression in breast cancer
A. Kaunisto, W. S. Henry, L. Montaser-Kouhsari , S.-C. Jaminet , E.-Y. Oh, L. Zhao, H. R. Luo, A. H. Beck, A. Toker , Molecular Oncology , DOI: 10.1016/j.molonc.2015.02.004
NFAT transcription factors are key regulators of gene expression in immune cells. In addition, NFAT1-induced genes play diverse roles in mediating the progression of various solid tumors. Here we show that NFAT1 induces the expression of the IL8 gene by binding to its promoter and leading to IL8 secretion. Thapsigargin...