Aug 12, 2013
Automated Segmentation and Object Classification of CT Images: Application to In Vivo Molecular Imaging of Avian Embryos
Heidrich A, Schmidt J, Zimmermann J, Saluz HP , Int J Biomed Imaging , Volume 2013, doi:10.1155/2013/508474
Although chick embryogenesis has been studied extensively, there has been growing interest in the investigation of skeletogenesis. In addition to improved poultry health and minimized economic loss, a greater understanding of skeletal abnormalities can also have implications for human medicine. True in vivo studies require noninvasive imaging techniques such as...
Aug 8, 2013
CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance
Putz EM, Gotthardt D, Hoermann G, Csiszar A, Wirth S, Berger A, Straka E, Rigler D, Wallner B, Jamieson AM, Pickl WF, Zebedin-Brandl EM, Müller M, Decker T, Sexl V , Cell Reports , DOI: 10.1016/j.celrep.2013.07.012
The transcription factor STAT1 is important in natural killer (NK) cells, which provide immediate defense against tumor and virally infected cells. We show that mutation of a single phosphorylation site (Stat1-S727A) enhances NK cell cytotoxicity against a range of tumor cells, accompanied by increased expression of perforin and granzyme B....
Aug 4, 2013
An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy
A. S. Chung, X. Wu, G. Zhuang, H. Ngu, I. Kasman, J. Zhang, J. M. Vernes, Z. Jiang, Y. G. Meng, F. V. Peale, W. Ouyang, N. Ferrara , Nature Medicine , DOI: 10.1038/nm.3291
Although angiogenesis inhibitors have provided substantial clinical benefit as cancer therapeutics, their use is limited by resistance to their therapeutic effects. While ample evidence indicates that such resistance can be influenced by the tumor microenvironment, the underlying mechanisms remain incompletely understood. Here, we have uncovered a paracrine signaling network between...
Jul 26, 2013
Prognostic significance of phospho-histone H3 in prostate carcinoma
M. Nowak, M. A. Svensson, J. Carlsson, W. Vogel, M. Kebschull, N. Wernert, G. Kristiansen, O. Andrén, M. Braun, S. Perner , World Journal of Urology , DOI: 10.1007/s00345-013-1135-y
Purpose: Prostate cancer is the second most common cancer in men and the sixth most common cause of death from cancer in men worldwide. Currently, a sufficient pathological distinction between patients requiring further treatment and those for which active surveillance remains an option is still lacking, which leads to the...
Jul 25, 2013
Rapamycin extends murine lifespan but has limited effects on aging
F. Neff, D. Flores-Dominguez, D. P. Ryan, M. Horsch, S. Schröder, T. Adler, L. C. Afonso, J. A. Aguilar-Pimentel, L. Becker, L. Garrett, W. Hans, M. M. Hettich, R. Holtmeier, S. M. Hölter, K. Moreth, C. Prehn, O. Puk, I. Rácz, B. Rathkolb, J. Rozman, B. Naton, R. Ordemann, J. Adamski, J. Beckers, R. Bekeredjian, D. H. Busch, G. Ehninger, J. Graw, H. Höfler, M. Klingenspor, T. Klopstock, M. Ollert, J. Stypmann, E. Wolf, W. Wurst, A. Zimmer, H. Fuchs, V. Gailus-Durner, M. Hrabe de Angelis, D. Ehninger , The Journal of Clinical Investigation , DOI: 10.1172/JCI67674
Aging is a major risk factor for a large number of disorders and functional impairments. Therapeutic targeting of the aging process may therefore represent an innovative strategy in the quest for novel and broadly effective treatments against age-related diseases. The recent report of lifespan extension in mice treated with the...