Quantitative Image Analysis in Preclinical and Clinical Drug Discovery - Why Count When You Can Code?
Frauke Bentzien, Director Clinical Science Exelixis, San Francisco, CA
Throughout history, shedding light on objects of interest has been at the center of scientific inquiry and has formed the basis for advances in modern pathological practices. The precision and speed of digital image acquisition enables pathologists and researchers to intelligently capture, store, access, search, and globally share stained histological...
Image Analysis, an Indispensable Tool for the Future of Medicine
Gerd Binnig, Founder and CTO Definiens, Munich, Germany
In medical R&D as well as in the clinical routine images play an important role. This role is getting even more decisive when targeted therapy becomes more and more the method of choice. Images are vital for R&D of targeted drugs and companion diagnostics and in the clinical routine in...
Translational Lung Cancer Research
Sven Perner, Institute of Pathology, University Hospital Bonn, Germany
Quantification of protein expression based on immunohistochemical stainings (IHC) is important for translational research. Several eyeballing scoring systems are used in order to semi-quantify the protein expression based on chromagen intensities of the targeted protein. However, for large-scale IHC studies, eyeballing scoring systems are time-consuming and subject to significant inter/intra-observer...
Image Analysis in Translational Research: Benefits and Challenges within Pharmaceutical R&D
Lorcan Sherry, OracleBio, Glasgow, UK
Translational research approaches that incorporate well defined biomarker strategies are now established as an integral component of the Pharmaceutical R&D process. For large Pharma undertaking pre-clinical R&D studies through to large scale clinical trials, the incorporation of target, drug response and therapeutic/diseased-focused biomarkers is key to helping make informed decisions...
Unlocking the Value of Digital Pathology with Image Analysis
Ole Eichhorn, Aperio, Vista, CA
Digital pathology is a rapidly emerging technology that streamlines biomarker discovery and enables pathologists to be more effective in supporting the patient’s care team. Image analysis has historically been a catalyst in the adoption of digital pathology, and has the potential to be instrumental in unlocking the future value of...