Scientific Talks

Scientific Talks

May 14, 2013

The Medical Value of Digital Pathology

Dr. Ralf Huss, Chief Medical Officer Definiens AG, Munich

Surgical pathology is still largely conducted manually while the complexity in clinical diagnostics grows almost exponentially. Clinicians increasingly challenge the pathologist to reasonably stratify each particular patient according to the patient’s individual cancer biology. Although new molecular technologies provide additional data based on the tumor’s genotype and other -omics tools,...

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May 14, 2013

Optimizing Efficiency of a Clinical Molecular Diagnostic Assay using an Integrated, Fully- Automated Image Analysis Workflow

Dr Tom Nifong, Vice President of Clinical Operations Metamark Genetics, Cambridge, MA

Efficiently incorporating quantitative image analysis into a clinical molecular laboratory is challenging. Quantitative image analysis requires a combination of traditional anatomic pathology tools for managing and staining tissue slides, clinical pathology systems for handling quantitative patient and quality control data, and robust image acquisition and analysis platforms. Image file management,...

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May 14, 2013

Millennium Pharmaceuticals: A Business Case Study for Utilizing the Definiens Platform in Multiple Image Analysis Workflows for IHC-based Biomarkers in Preclinical and Clinical Models

Dr Doug Bowman, Senior Scientist II Millennium Pharmaceuticals, Cambridge, MA

A fundamental challenge in oncology drug discovery is determining if a drug has affected the intended biological target. This is important from the early stages of drug discovery to the later stages of drug development. Immunohistochemistry (IHC) based biomarkers play an important role in understanding target inhibition as well as...

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May 14, 2013

Integrating Definiens in the Molecular Pathology Workflow

Dr Thomas T. Tibbitts, Research Director Infinity Pharmaceuticals, Cambridge, MA

Development of personalized medicine requires a reliable and efficient method to manage and track patient samples, their derivatives, and research findings over the course of a drug development cycle. Our research informatics infrastructure supports biospecimen sample tracking, integrates our slide stainers and digital imaging systems, and establishes standard processes to...

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May 14, 2013

Beyond the “Nuclear Option”: Sophisticated Digital Analysis Adds Value to Researchers’ Work and to a Core Lab’s Worth

Dr Clara E. Magyar, Manager, Translational Pathology Core Laboratory, Department of Pathology UCLA School of Medicine, Los Angeles, CA

The UCLA Translational Pathology Core Laboratory (TPCL) provides basic and sophisticated pathology services, including digital slide scanning and analysis, to support basic, translational and clinical research. Located in the Department of Pathology and Laboratory Medicine, this UCLA Jonsson Comprehensive Cancer Center Shared Facility serves both UCLA and non-UCLA academic and...

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