Dec 5, 2005
Hexagonal Packing of Drosophila Wing Epithelial Cells by the Planar Cell Polarity Pathway
A.-K. Classen, K. I. Anderson, E. Marois, S. Eaton , Developmental Cell , DOI: 10.1016/j.devcel.2005.10.016
The mechanisms that order cellular packing geometry are critical for the functioning of many tissues, but they are poorly understood. Here, we investigate this problem in the developing wing of Drosophila. The surface of the wing is decorated by hexagonally packed hairs that are uniformly oriented by the planar cell...
Jul 7, 2005
Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis
L. Pelkmans, E. Fava, H. Grabner, M. Hannus, B. Habermann, E. Krausz, M. Zerial , nature , DOI: 10.1038/nature03571
Endocytosis is a key cellular process, encompassing different entry routes and endocytic compartments. To what extent endocytosis is subjected to high-order regulation by the cellular signalling machinery remains unclear. Using high-throughput RNA interference and automated image analysis, we explored the function of human kinases in two principal types of endocytosis:...